DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip84 and Tubgcp2

DIOPT Version :9

Sequence 1:	NP_728264.1	Gene:	Grip84 / 32946	FlyBaseID:	FBgn0026430	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001101030.1	Gene:	Tubgcp2 / 309098	RGDID:	1309597	Length:	905	Species:	Rattus norvegicus

Alignment Length:	943	Identity:	297/943 - (31%)
Similarity:	482/943 - (51%)	Gaps:	117/943 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EFRATSD-------RRLPACDLIKVLVSISEKRPNFAEVTKEISHILQNKDPMYALLV--FVERY 85
            |||...|       .|:...|..:|.:.:.:|.......|...:|..:.|...::...  |:::|
  Rat     3 EFRIHHDVNELLSLLRIHGGDGAEVYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTPEDFLKKY 67

  Fly    86 SECKPVSESSSSTSLSAMGLPHGNKTSDVNSAAGSVPTTLAIASTSTILTTSQNVSGSTRLSLTQ 150
            .|.|    |.::.:|..:.......|.|                ..|:....||......|:.:.
  Rat    68 DELK----SKNTRNLDPLVYLLSKLTED----------------KETLQYLQQNAKERAELAASA 112

  Fly   151 SQDFPT--STPVNCKKATESDTTPVVFVRRGPMDRNRGAGKDERNDLSVIKERVLNAVSDQSLSG 213
            :....|  |.||                         .|.|....:|..:::::.:..:..:|..
  Rat   113 AASSATGFSIPV-------------------------AASKMSTQELEELRKQLGSVATGSTLQQ 152

  Fly   214 YRSVTNKTGNSPKSMPNDLVTLTDVPDEYRTHLLWEYYK--VDGD-----------KVPRAEIAA 265
            ...:|.|.....::..|....|...|       .|.|.:  :.||           .:|   |..
  Rat   153 SLELTRKMLRDKQNKKNSGQPLPVFP-------AWVYERPTLAGDFLIGSGLSSDTTLP---IGT 207

  Fly   266 MPLLSQESMLLDELLHCLTGIRESLLVPQKPIISAVGLAKYDTDFDIHTHLDRSLTHQVREILPL 330
            :||.||||.::::||:.|.|: :...:..:|:     ..:.:..|.:..:||.|:...|..|||:
  Rat   208 LPLASQESAVVEDLLYVLVGV-DGRYITAQPL-----AGRQNRTFLVDPNLDLSIRELVNRILPV 266

  Fly   331 ASYFMGVQKIIAATDGL--GQVMNSLNEALQELTHDFYLIIVQAEQELRHNRLTLQKLLYYLQPT 393
            |:.:..|.:.|......  |||.::|..|::.|..::.:::.|.||..|...|:||||.:|:||.
  Rat   267 AASYSTVTRFIEEKSSFEYGQVNHALAAAMRTLVKEYLILVTQLEQLHRQGLLSLQKLWFYIQPA 331

  Fly   394 MWVMHEVWSSLVIIQLSDSRDAEVLTYLHERIKRLEGNKDAQQLIIGLVRKAAKPYMRMLQMWIQ 458
            |..:..:.|....:...:......|:.||:|.....|:..||:|.:.|.:.|:.||..:|:.||.
  Rat   332 MRTIDILASLATSVDKGECVGGSTLSLLHDRSFNYTGDSQAQELCLYLTKAASAPYFEILEEWIY 396

  Fly   459 KGVIVDRHREFLVVDNEVIHRDELPEHYSDDYWERRYTLRDEQIPSFLAKYSDKILRTGKYLNVI 523
            :|||.|.:.||:|.::| :.::::.|.|:|.||::|||:..:||||||.|.:.|||.|||||||:
  Rat   397 RGVIHDPYSEFMVEEHE-LRKEKIQEDYNDKYWDQRYTVLPQQIPSFLQKVAGKILSTGKYLNVV 460

  Fly   524 RQCGKRVMPTQEMNLEFDPTSERHVSVINDAYYFAARMLLDVLLTENDLMGHLQSVKRYLLLNQG 588
            |:||..|.......:.:......:|..|..|:.:|:::|||.|:.|.:|:.||:|:|||.|::||
  Rat   461 RECGHDVTCPVAKEIIYTLKERAYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFLMDQG 525

  Fly   589 DFTMQFMDACEDELTKNVDHVLPMTLENLLGLTLRISSARNDPYKDDLHCELLPYDLVTQMSKIM 653
            ||.:.|||..|:||.|.|:.:.|..||.||.|.||:|:|..||:||||..:|:|:||:||:.:::
  Rat   526 DFFVHFMDLTEEELRKPVEDITPTRLEALLELALRMSTANTDPFKDDLKIDLMPHDLITQLLRVL 590

  Fly   654 KKEENWQ-----AQP-RLDLSGLECFAFTYEVKWPCSLVLNHISISKYQMLFRQLFYCKHVERQL 712
            ..|...:     |.| .|.|||||.|:|.|.||||.||::|..::::||||||.:||||||||||
  Rat   591 AIETKQEKAMTHADPTELTLSGLEAFSFDYMVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQL 655

  Fly   713 CKIWKENSIARQFEPQAASLYRAAFTLRQRMMNAIQNLEYYMMIEIIEPNWHIFIEKMKTVENVD 777
            |.:|..|..|:|....:|..:..||||||||:|.:||::||||.|::||.|||..:.:|:..|:|
  Rat   656 CSVWISNKTAKQHALHSAKWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEKNLKSASNID 720

  Fly   778 NVLRLHQDFLDSCLKNCMLTESSHLNRSIFKLCKICLKYCEFIQ-ITQRYFQDAELRSMVRDSA- 840
            :||..|..|||:|||:|||| :..|.:...||..:|:.:...:| .||....|:||..:..|..
  Rat   721 DVLGHHTSFLDNCLKDCMLT-NPELLKVFSKLMSVCVMFTNCMQKFTQSMKLDSELGRLTLDQGS 784

  Fly   841 ------------DSSESEQESLHCPQ-IETPLDPTDTFSERVRRFDLEFTQLLISFLKQINSMAK 892
                        |....|....|.|: ::|| ..:..|...:..||..|:..|:..|.:::..
  Rat   785 VQGPPPESERIDDRPRKEPTRKHLPEHVDTP-QLSSGFEATINNFDKNFSAHLLDLLARLSVY-- 846

  Fly   893 KNTADC---FMNLVHRINFNAFYTDQMDKMCVE 922
             :|:||   ..:::.|::||.||.::::::..|
  Rat   847 -STSDCEHGMASVISRLDFNGFYAERLERLSAE 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip84	NP_728264.1	Spc97_Spc98	278..795	CDD:282045	213/524 (41%)
Tubgcp2	NP_001101030.1	GCP_N_terminal	218..506	CDD:407574	96/294 (33%)
Tubgcp2	NP_001101030.1	Spc97_Spc98	509..868	CDD:398000	149/363 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337641
Domainoid	1	1.000	284	1.000	Domainoid score	I1551
eggNOG	1	0.900	-	-		E1_KOG2001
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55980
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1455
OMA	1	1.010	-	-		QHG56391
OrthoDB	1	1.010	-	-		D124154at33208
OrthoFinder	1	1.000	-	-		FOG0005184
OrthoInspector	1	1.000	-	-		oto96885
orthoMCL	1	0.900	-	-		OOG6_101900
Panther	1	1.100	-	-	LDO	PTHR19302
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4216
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770