Protein Alignment Grip84 and TUBGCP4

DIOPT Version :10

• Sequence 1: NP_728264.1
• Gene: Grip84 / 32946
• FlyBaseID: FBgn0026430
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_001273343.1
• Gene: TUBGCP4 / 27229
• HGNCID: 16691
• Length: 667
• Species: Homo sapiens
• Alignment Length: 757
• Identity: 148/757 - (19%)
• Similarity: 276/757 - (36%)
• Gaps: 219/757 - (28%)

  Fly   275 LLDELLHCLTGI---------RESLLVPQ-----KPIISAV--GLAKYDTDFDIHTHLDRSLTHQ 323
            ::.|||..|:|.         |..|.|.|     .|..::|  .|.:..||:...|......|..
Human     1 MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIEQYTGH 65

  Fly   324 V--REILPLASYFMGVQKII--AATDGLGQVMNSLNEALQELTHDFYLIIVQAEQELRHNRLTLQ 384
            |  ::..|......|:..|.  |...||..|:....:||.:|..:|          |....|::.
Human    66 VQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEF----------LGDPHLSIS 120

  Fly   385 KLLYYLQPTMWVMHEVWSSLVIIQLSDSRDAEVLTYLHERIKRLEGNKDAQQLIIGL--VRKAAK 447
            .:.|:|.....:...|   :|:::...|:.......|....|...|         ||  ||.|.:
Human   121 HVNYFLDQFQLLFPSV---MVVVEQIKSQKIHGCQILETVYKHSCG---------GLPPVRSALE 173

  Fly   448 PYM--------RMLQMWIQKGVIVDRHREFLVVDNEVI-HRDELPEHYSDDYW------------ 491
            ..:        :.|..|:..|:::|:|.||.:...... :....||...:|..
Human   174 KILAVCHGVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLREL 238

  Fly   492 ---------------ERRYTLRDEQIPSFL-AKYSDKILRTG--------KYLNVIRQCGKRVMP 532
                           .::::||.|.:||:: .:.::|||..|        :.:|:.|:  ..::.
Human   239 QDLRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQNVNLTRK--GSILK 301

  Fly   533 TQEMN----------------LEFDPTSERHVSVINDAYYFAARMLLDVLLTENDLMGHLQSVKR 581
            .||..                ::|:...:|..|.:       |..|..:::.|:||:|.|:.:|.
Human   302 NQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTV-------AEHLWKLMVEESDLLGQLKIIKD 359

  Fly   582 YLLLNQGDFTMQFMDACEDELTK----------NV-------------DHVLPMTLENLLGLTLR 623
            :.||.:|:....|:|..:..|..          ||             |::||     ||.||:.
Human   360 FYLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLP-----LLHLTIE 419

  Fly   624 ISSARNDPYKDDLHCELLPYDLVTQMSKIMKKEENWQAQPRLDLSGLECFAFTYEVKWPCSLVLN 688
            .   ....:|.|          .||..:...:|.:.:..|   .||......:|:|:||..::..
Human   420 Y---HGKEHKAD----------ATQAREGPSRETSPREAP---ASGWAALGLSYKVQWPLHILFT 468

  Fly   689 HISISKYQMLFRQLFYCKHVERQLCKIWKENSIARQFEPQAASLYRAAFTLRQRMMNAIQNLEYY 753
            ...:.||.::|:.|...:.|:.:|...|......:..:.......:  :.||..|...:.||:||
Human   469 PAVLEKYNVVFKYLLSVRRVQAELQHCWALQMQRKHLKSNQTDAIK--WRLRNHMAFLVDNLQYY 531

  Fly   754 MMIEIIEPNWHIFIEKMKTVENVDNVLRLHQDFLDSCLKNCMLTESSHLNRSIF----KLCKICL 814
            :.::::|..:...:.::.:..:.:::...|..||.:     :|.:|..|.:.:|    ::..:|.
Human   532 LQVDVLESQFSQLLHQINSTRDFESIRLAHDHFLSN-----LLAQSFILLKPVFHCLNEILDLCH 591

  Fly   815 KYCEFIQITQRYFQDAELRSMVRDSADSSESEQESLHCPQIETPLDPTDT--FSERVRRFDLEFT 877
            .:|..:.                                |...|||....  .|..|:.|..: :
Human   592 SFCSLVS--------------------------------QNLGPLDERGAAQLSILVKGFSRQ-S 623

  Fly   878 QLLISFLK-----QINS-MAKKNTADCFMNLVHRINFNAFYT 913
            .||...|.     |||| :|:         |:.|:::|.:||
Human   624 SLLFKILSSVRNHQINSDLAQ---------LLLRLDYNKYYT 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip84	NP_728264.1	GCP_N_terminal	276..569	CDD:465456	71/375 (19%)
		GCP_C_terminal	572..912	CDD:461187	73/374 (20%)
TUBGCP4	NP_001273343.1	GCP_N_terminal	2..347	CDD:465456	71/375 (19%)
		GCP_C_terminal	350..655	CDD:461187	73/374 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..445		5/29 (17%)