DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip84 and Tubgcp3

DIOPT Version :9

Sequence 1:	NP_728264.1	Gene:	Grip84 / 32946	FlyBaseID:	FBgn0026430	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_932148.1	Gene:	Tubgcp3 / 259279	MGIID:	2183752	Length:	905	Species:	Mus musculus

Alignment Length:	1004	Identity:	209/1004 - (20%)
Similarity:	382/1004 - (38%)	Gaps:	230/1004 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LRGVLANLISESQSPLTPESIIREF----RATSDRRLPACDLIKVLVS-------ISEKRPNFAE 60
            |:.:...::..|::     .:.::|    |.......|..:..:.||:       |.::|...|.
Mouse    13 LQNLCCRILGRSEA-----DVAQQFQFAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAA 72

  Fly    61 VTKEISH------ILQNKDPMYALLVFVERYSE--CKPVSESSSSTSLSAMGLPH-GNKTSDVNS 116
            :..|:..      :|:||   :::|..:...||  .|..|:.:|..||.|..||. .:.|....:
Mouse    73 LFSELHRKLHSQGVLKNK---WSILYLLLNLSEDPRKQASKVTSYASLFAQALPRDAHSTPYYYA 134

  Fly   117 AAGSVPTTLAIASTSTILTTSQNVSGSTRLSLTQSQDFPTSTPVNCKKATESDTTPVVFVRRGPM 181
            ...::|......||....:.|...||.:.:.:             |..   |..|||.....|..
Mouse   135 RPQTLPLNYQDRSTQAQSSGSLGSSGISSIGM-------------CGL---SGPTPVQPFLPGQS 183

  Fly   182 DRNRGAGKDERNDLSVIKERVLNAVSDQSLSGYRSVTNKTGNSPKSMPNDLVTLTDVPDEYRTHL 246
            .:..|.|...|..|                 |.|.....|||.|.|   ...|....|:....:|
Mouse   184 HQAPGVGDGLRQQL-----------------GPRLAWTLTGNQPSS---QTPTSKGFPNALSRNL 228

  Fly   247 LWEYYKVDGDKVPRAEIAAMPLLSQESMLLDELLHCLTGIRESLLVPQKPIISAVGLAKYDTD-- 309
            ...  :.:||.....|:.       |:.|:.::|:...|            |....:....|:
Mouse   229 TRS--RREGDPGGTLEVT-------EAALVRDILYVFQG------------IDGKNIKMSSTENC 272

  Fly   310 --FDIHTHLDRSLTHQVREILPLASYFMGVQKII---AATDGLGQVMNSLNEALQELTHDFY--L 367
              .:...:|::||......:..|......::|..   :.....|.|..|...||.:...::|  |
Mouse   273 YKVEAKANLNKSLRDTAVRLAELGWLHNKIRKYADQRSLDRSFGLVGQSFCAALHQELKEYYRLL 337

  Fly   368 IIVQAEQELRHNR---------LTLQKLLYYLQPTMWVMHEVWS----------SLVIIQLSDSR 413
            .::.::.:|..::         |||::||            ||:          :.::......:
Mouse   338 SVLHSQLQLEDDQGVNLGLESSLTLRRLL------------VWTYDPKIRLKTLAALVDHCQGRK 390

  Fly   414 DAEVLTYLHERIKRLEGNKDAQQLIIGLVRKAAKPYMRMLQMWIQKGVIVDRHREFLVVDNEVIH 478
            ..|:.:.:|...|  .|:...:.|:..::...:.|.:..|..||..|.:.|.:.||.|..:..:.
Mouse   391 GGELASAVHAYTK--TGDPYMKSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVK 453

  Fly   479 RDELPEHYSDDYWERRYTLRDEQIPSFLA-KYSDKILRTGKYLNVIRQCGKRVMPTQEM-----N 537
            .|.|        |..:||||...||||:. ..|.|:|..||.:|.:.|......||.:|     :
Mouse   454 TDRL--------WHDKYTLRKSMIPSFITMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKS 510

  Fly   538 LE--------FDPTSERHVSVINDAYYFAARMLLDVLLTENDLMGHLQSVKRYLLLNQGDFTMQF 594
            .|        |..........|:.||:..::.|||||..:..|:.|:|:::|||||.||||....
Mouse   511 AESPRDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLEHMQAMRRYLLLGQGDFIRHL 575

  Fly   595 MDACEDELTKNVDHVLPMTLENLLGLTLRISSARNDPYKDDLHCELLPYDLVTQMSKIMKKEENW 659
            ||..:.||.:....:....|..:|...:|.::|:.|                  ..:|:|
Mouse   576 MDLLKPELVRPATTLYQHNLTGILETAVRATNAQFD------------------SPEILK----- 617

  Fly   660 QAQPRLDL---------SGLECFAFTYEVKWPCSLVLNHISISKYQMLFRQLFYCKHVERQLCKI 715
                |||:         :|.:.|:..|.|..|.:.|.....:|.|..:|..|:..|.:|..|..|
Mouse   618 ----RLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDI 678

  Fly   716 WKE---NSIARQFEPQAASLYRAAFTLRQRMMNAIQNLEYYMMIEIIEPNWHIFIEKMKTVENVD 777
            .|.   |:...:..|:.:.:......|...|::.|..::||:..|::|.:|.....:::..:::|
Mouse   679 RKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNRVQQAQDLD 743

  Fly   778 NVLRLHQDFLDSCLKNCMLTESSH--LN--RSIF-KLCKI----CLKYCEFIQITQRYFQDAELR 833
            :::..|:.||::....|:|..:|.  ||  |::| ::.::    .:.|...::..||..|..|.:
Mouse   744 HIIAAHEAFLNTITSRCLLDSNSRVLLNQLRAVFDQIIELQNAQDVMYRAALEELQRRLQFEEKK 808

  Fly   834 SMVRD-----SADSSESEQESLHCPQIETPLDPTDTFSERVRRFDLEF----TQLLI------SF 883
            .. |:     ...::|.|:|                 ::|:|.|....    :||.|      ..
Mouse   809 KQ-REIEGQWGVTAAEEEEE-----------------NKRIREFQDSIPKMCSQLRILTHFYQGV 855

  Fly   884 LKQINSMAKKNTADCFMNLVHRINFNAFY 912
            ::|...:...::.:....|..|::||..|
Mouse   856 VQQFLVLLTTSSDESLQFLSFRLDFNEHY 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip84	NP_728264.1	Spc97_Spc98	278..795	CDD:282045	124/570 (22%)
Tubgcp3	NP_932148.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..193		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..239		10/37 (27%)
		Spc97_Spc98	251..761	CDD:282045	124/570 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D124154at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920