DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip84 and TUBGCP2

DIOPT Version :9

Sequence 1:	NP_728264.1	Gene:	Grip84 / 32946	FlyBaseID:	FBgn0026430	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001243546.1	Gene:	TUBGCP2 / 10844	HGNCID:	18599	Length:	930	Species:	Homo sapiens

Alignment Length:	954	Identity:	304/954 - (31%)
Similarity:	486/954 - (50%)	Gaps:	118/954 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLANLISESQSPLTPESI--------IREFRATSDRRLPACDLIKVLVSISEKRPNFAEVTKEIS 66
            |..:|:.::::|....::        |.||..|.:..|...|.:|     |:...|...:...:|
Human    27 VYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTPEDFLKKYDELK-----SKNTRNLDPLVYLLS 86

  Fly    67 HILQNKDPMYALLVFVERYSECKPVSESSSSTSLSAMGLPHGNKTS-----DVNSAAGSVPTTLA 126
            .:.::|:.:..|....:..:|....:..||:||::....  .:|.|     ::....|||.|.
Human    87 KLTEDKETLQYLQQNAKERAELAAAAVGSSTTSINVPAA--ASKISMQELEELRKQLGSVATG-- 147

  Fly   127 IASTSTILTTSQNVSGSTRLSLTQSQDFPTSTPVNCKKATESDTTPV--VFVRRGPM---DRNRG 186
                    :|.|......|..|...|:          |.......|:  .:|...|.   |...|
Human   148 --------STLQQSLELKRKMLRDKQN----------KKNSGQHLPIFPAWVYERPALIGDFLIG 194

  Fly   187 AGKDERNDLSVIKERVLNAVSDQ-SLSGYRSVTNKTGNSPKSMPNDLVTLTDVPDEYRTHLLWEY 250
            ||......|.::..|...|:|.: ..||..|.                       ....||
Human   195 AGISTDTALPIVLLRWNLALSPRLKCSGVISA-----------------------HCNLHL---- 232

  Fly   251 YKVDGDKVPRAEIAAMPLLSQESMLLDELLHCLTGIRESLLVPQKPIISAVGLAKYDTDFDIHTH 315
                    |    ..:||.||||.::::||:.|.|: :...|..:|:     ..:....|.:..:
Human   233 --------P----GTLPLASQESAVVEDLLYVLVGV-DGRYVSAQPL-----AGRQSRTFLVDPN 279

  Fly   316 LDRSLTHQVREILPLASYFMGVQKIIAATDGL--GQVMNSLNEALQELTHDFYLIIVQAEQELRH 378
            ||.|:...|..|||:|:.:..|.:.|......  |||.::|..|::.|..:..:::.|.||..|.
Human   280 LDLSIRELVHRILPVAASYSAVTRFIEEKSSFEYGQVNHALAAAMRTLVKEHLILVSQLEQLHRQ 344

  Fly   379 NRLTLQKLLYYLQPTMWVMHEVWSSLVIIQLSDSRDAEVLTYLHERIKRLEGNKDAQQLIIGLVR 443
            ..|:||||.:|:||.|..|..:.|....:...:......|:.||:|.....|:..||:|.:.|.:
Human   345 GLLSLQKLWFYIQPAMRTMDILASLATSVDKGECLGGSTLSLLHDRSFSYTGDSQAQELCLYLTK 409

  Fly   444 KAAKPYMRMLQMWIQKGVIVDRHREFLVVDNEVIHRDELPEHYSDDYWERRYTLRDEQIPSFLAK 508
            .|:.||..:|:.||.:|:|.|.:.||:|.::| :.::.:.|.|:|.||::|||:..:||||||.|
Human   410 AASAPYFEVLEKWIYRGIIHDPYSEFMVEEHE-LRKERIQEDYNDKYWDQRYTIVQQQIPSFLQK 473

  Fly   509 YSDKILRTGKYLNVIRQCGKRVMPTQEMNLEFDPTSERHVSVINDAYYFAARMLLDVLLTENDLM 573
            .:||||.|||||||:|:||..|.......:.:......:|..|..|:.:|:::|||.|:.|.:|:
Human   474 MADKILSTGKYLNVVRECGHDVTCPVAKEIIYTLKERAYVEQIEKAFNYASKVLLDFLMEEKELV 538

  Fly   574 GHLQSVKRYLLLNQGDFTMQFMDACEDELTKNVDHVLPMTLENLLGLTLRISSARNDPYKDDLHC 638
            .||:|:|||.|::||||.:.|||..|:||.|.|:.:.|..||.||.|.||:|:|..||:||||..
Human   539 AHLRSIKRYFLMDQGDFFVHFMDLAEEELRKPVEDITPPRLEALLELALRMSTANTDPFKDDLKI 603

  Fly   639 ELLPYDLVTQMSKIM---KKEENWQAQ---PRLDLSGLECFAFTYEVKWPCSLVLNHISISKYQM 697
            :|:|:||:||:.:::   .|:|...|.   ..|.|||||.|:|.|.||||.||::|..::::|||
Human   604 DLMPHDLITQLLRVLAIETKQEKAMAHADPTELALSGLEAFSFDYIVKWPLSLIINRKALTRYQM 668

  Fly   698 LFRQLFYCKHVERQLCKIWKENSIARQFEPQAASLYRAAFTLRQRMMNAIQNLEYYMMIEIIEPN 762
            |||.:|||||||||||.:|..|..|:|....:|..:..||||||||:|.:||::||||.|::||.
Human   669 LFRHMFYCKHVERQLCSVWISNKTAKQHSLHSAQWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPT 733

  Fly   763 WHIFIEKMKTVENVDNVLRLHQDFLDSCLKNCMLTESSHLNRSIFKLCKICLKYCEFIQ-ITQRY 826
            |||..:.:|:..|:|:||..|..|||:|||:|||| :..|.:...||..:|:.:...:| .||..
Human   734 WHILEKNLKSASNIDDVLGHHTGFLDTCLKDCMLT-NPELLKVFSKLMSVCVMFTNCMQKFTQSM 797

  Fly   827 FQDAELRSMVRD-------SADSSESEQESL---HCPQIETPLDPTDTFSERVRRFDLEFTQLLI 881
            ..|.||.....:       .|.:.|..::.|   |..:....:.....|...:.:||..|:..|:
Human   798 KLDGELGGQTLEHSTVLGLPAGAEERARKELARKHLAEHADTVQLVSGFEATINKFDKNFSAHLL 862

  Fly   882 SFLKQINSMAKKNTADC---FMNLVHRINFNAFYTDQMDKMCVE 922
            ..|.:::..   :|:||   ..:::.|::||.|||::::::..|
Human   863 DLLARLSIY---STSDCEHGMASVISRLDFNGFYTERLERLSAE 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip84	NP_728264.1	Spc97_Spc98	278..795	CDD:282045	215/524 (41%)
TUBGCP2	NP_001243546.1	GCP_N_terminal	246..534	CDD:407574	98/294 (33%)
TUBGCP2	NP_001243546.1	Spc97_Spc98	537..893	CDD:398000	146/359 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143864
Domainoid	1	1.000	280	1.000	Domainoid score	I1696
eggNOG	1	0.900	-	-		E1_KOG2001
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55980
Inparanoid	1	1.050	472	1.000	Inparanoid score	I1520
Isobase	1	0.950	-	0	Normalized mean entropy	S5476
OMA	1	1.010	-	-		QHG56391
OrthoDB	1	1.010	-	-		D124154at33208
OrthoFinder	1	1.000	-	-		FOG0005184
OrthoInspector	1	1.000	-	-		oto89770
orthoMCL	1	0.900	-	-		OOG6_101900
Panther	1	1.100	-	-	LDO	PTHR19302
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R53
SonicParanoid	1	1.000	-	-		X4216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750