Protein Alignment Grip84 and TUBGCP3

DIOPT Version :10

• Sequence 1: NP_728264.1
• Gene: Grip84 / 32946
• FlyBaseID: FBgn0026430
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_006313.1
• Gene: TUBGCP3 / 10426
• HGNCID: 18598
• Length: 907
• Species: Homo sapiens
• Alignment Length: 1010
• Identity: 213/1010 - (21%)
• Similarity: 370/1010 - (36%)
• Gaps: 303/1010 - (30%)

  Fly     3 KPHALRGVLAN-------LISESQSPLTPESIIREFRATSDRRLPACDLIKVLVSISEKRPNFAE 60
            |.|: :|||.|       |:|.|:.|               ||.|:        .:|.....||:
Human    80 KLHS-QGVLKNKWSILYLLLSLSEDP---------------RRQPS--------KVSSYATLFAQ 120

  Fly    61 VTKEISHILQNKDPMYAL------LVFVERYSECKPVSESSSSTSLSAMGLPHGNKTSDVNSAAG 119
            .....:|    ..|.|..      |.:.:|.::....|.|..|:.:|::||         .:.:|
Human   121 ALPRDAH----STPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGL---------CALSG 172

  Fly   120 SVPTTLAIASTSTILTTSQNVSG---------STRLSLTQSQDFPTSTPVNCKKATESDTTPVVF 175
            ..|     |..|.:...|....|         .:||:.|.:.:.|:|      :||.|...|...
Human   173 PAP-----APQSLLPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSS------QATTSKGVPSAV 226

  Fly   176 VRRGPMDRNRG--AGKDERNDLSVIKERVLNAVSDQSLSGYRSVTNKTGNSPKSMPNDLVTLTDV 238
            .|.....|..|  .|..|..:.::::: :|...  |.:.|.....|.|.|.
Human   227 SRNMTRSRREGDTGGTMEITEAALVRD-ILYVF--QGIDGKNIKMNNTENC-------------- 274

  Fly   239 PDEYRTHLLWEYYKVDGDKVPRAEIAAMPLLSQESMLLDEL--LHCLTGIRESLLVPQKPIISAV 301
                        |||:|    :|.::..  |...::.|.||  ||  ..||
Human   275 ------------YKVEG----KANLSRS--LRDTAVRLSELGWLH--NKIR-------------- 305

  Fly   302 GLAKYDTDFDIHTHLDRSLTHQVREILPLASYFMGVQKIIAATDGLGQVMNSLNEALQELTHDFY 366
               :| ||   ...||||                           .|.|..|...||.:...::|
Human   306 ---RY-TD---QRSLDRS---------------------------FGLVGQSFCAALHQELREYY 336

  Fly   367 --LIIVQAEQELRHNR---------LTLQKLLYYLQPTMWVMHEVWS----------SLVIIQLS 410
              |.::.::.:|..::         |||::||            ||:          :.::....
Human   337 RLLSVLHSQLQLEDDQGVNLGLESSLTLRRLL------------VWTYDPKIRLKTLAALVDHCQ 389

  Fly   411 DSRDAEVLTYLHERIKRLEGNKDAQQLIIGLVRKAAKPYMRMLQMWIQKGVIVDRHREFLVVDNE 475
            ..:..|:.:.:|...|  .|:...:.|:..::...:.|.:..|..||..|.:.|.:.||.|..:.
Human   390 GRKGGELASAVHAYTK--TGDPYMRSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDP 452

  Fly   476 VIHRDELPEHYSDDYWERRYTLRDEQIPSFLA-KYSDKILRTGKYLNVIRQCGKRVMPTQEM--- 536
            .:..|.|        |..:||||...||||:. ..|.|:|..||.:|.:.|......||.:|
Human   453 TVKTDRL--------WHDKYTLRKSMIPSFMTMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAV 509

  Fly   537 --NLE--------FDPTSERHVSVINDAYYFAARMLLDVLLTENDLMGHLQSVKRYLLLNQGDFT 591
              :.|        |..........|:.||:..::.|||||..:..|:.|:|:::|||||.||||.
Human   510 TKSAESPQDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFI 574

  Fly   592 MQFMDACEDELTKNVDHVLPMTLENLLGLTLRISSARNDPYKDDLHCELLPYDLVTQMSKIMKKE 656
            ...||..:.||.:....:....|..:|...:|.::|:.|                  ..:|::
Human   575 RHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFD------------------SPEILR-- 619

  Fly   657 ENWQAQPRLDL---------SGLECFAFTYEVKWPCSLVLNHISISKYQMLFRQLFYCKHVERQL 712
                   |||:         :|.:.|:..|.|..|.:.|.....:|.|..:|..|:..|.:|..|
Human   620 -------RLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYIL 677

  Fly   713 CKIWKE---NSIARQFEPQAASLYRAAFTLRQRMMNAIQNLEYYMMIEIIEPNWHIFIEKMKTVE 774
            ..|.|.   |:...:..|:.:.:......|...|::.|..::||:..|::|.:|.....|::..:
Human   678 TDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNKVQQAQ 742

  Fly   775 NVDNVLRLHQDFLDSCLKNCMLTESSH--LN--RSIFKLCKICLKYCEFIQITQRYFQDAELRSM 835
            ::|:::..|:.|||:.:..|:|...|.  ||  |::|.         :.|::...  |||..|:.
Human   743 DLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFD---------QIIELQNA--QDAIYRAA 796

  Fly   836 VRD--------------------SADSSESEQESLHCPQIETPLDPTDTFSERVRRFDLE---FT 877
            :.:                    ...::|.|:|:....:          |.|.:.:...:   .|
Human   797 LEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGE----------FKESIPKMCSQLRILT 851

  Fly   878 QLLISFLKQINSMAKKNTADCFMNLVHRINFNAFY 912
            ......::|...:...::.:....|..|::||..|
Human   852 HFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHY 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip84	NP_728264.1	GCP_N_terminal	276..569	CDD:465456	74/329 (22%)
		GCP_C_terminal	572..912	CDD:461187	79/378 (21%)
TUBGCP3	NP_006313.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..241		9/36 (25%)
		GCP_N_terminal	251..552	CDD:465456	86/407 (21%)
		GCP_C_terminal	555..886	CDD:461187	79/378 (21%)