DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip84 and tubgcp2

DIOPT Version :9

Sequence 1:	NP_728264.1	Gene:	Grip84 / 32946	FlyBaseID:	FBgn0026430	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	XP_002940353.2	Gene:	tubgcp2 / 100497706	XenbaseID:	XB-GENE-490453	Length:	896	Species:	Xenopus tropicalis

Alignment Length:	959	Identity:	300/959 - (31%)
Similarity:	490/959 - (51%)	Gaps:	154/959 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLANLISESQSPLTPESI--------IREFRATSDRRLPACDLIKVLVSISEKRPNFAEVTKEIS 66
            |..:|:.::::|....|:        |.||..|.|      |.:|....:..|.
Frog    27 VYIDLLQKNRTPYVTTSVSTHSAKVKIAEFSRTPD------DFLKKYEELKSKN----------- 74

  Fly    67 HILQNKDPMYALLVFVERYSECKPVSESSSSTSLSAMGLPHGN--KTSDVNSAAGSVPTTLAIAS 129
              .:|.||:..||        .|.:.:..:...|      |.|  ..:|:.|          |::
Frog    75 --TRNLDPLVYLL--------SKLIEDKETLQYL------HQNAKDKADLTS----------ISA 113

  Fly   130 TSTILTTSQNVSGSTRLSLTQSQDFPTSTPVNCKKATESDTTPVVFVRRGPMDRNRGAGKDERND 194
            |:..|..:.|.|   ::||.:..:...........|:.| ..||..:|:...|:
Frog   114 TAASLPVAPNTS---KISLHELDELRRQLETVTMAASYS-PQPVEVLRKCLRDK----------- 163

  Fly   195 LSVIKERVLNAVSDQSLSGYRSVTNKTGNSPKSMPNDLVTLTDVPDEYRTHLLWEYYK--VDGDK 257
               :|::                  .||:.....|:                 |.|.:  :.||.
Frog   164 ---LKKK------------------NTGHPVPVFPS-----------------WVYERPALTGDF 190

  Fly   258 VP--------RAEIAAMPLLSQESMLLDELLHCLTGIRESLLVPQKPIISAVGLAKYDTDFDIHT 314
            :|        ...|..:|:.|||:.|:::||:.|.|: :...:..:|::     ......|.:..
Frog   191 MPFSNSSTDVTVPIGTLPMPSQEACLVEDLLYILIGV-DGRYISVQPLV-----GHQSRTFSVEQ 249

  Fly   315 HLDRSLTHQVREILPLASYFMGVQKIIAATD--GLGQVMNSLNEALQELTHDFYLIIVQAEQELR 377
            :||.|:...|..|||:|:.:..|.:.:....  ..|||.::|..|::.|..::.::|.|.|...|
Frog   250 NLDMSVKELVNRILPVAANYSTVTRFVEENSLFEYGQVNHALGAAMRTLGKEYMILITQLEHLQR 314

  Fly   378 HNRLTLQKLLYYLQPTMWVMHEVWSSLVIIQLSDSRDAEVLTYLHERIKRLEGNKDAQQLIIGLV 442
            ...|:||||.:|:|||:..|..:.|....:...:......|:.||:|.....|:..||:|.:.|.
Frog   315 QGLLSLQKLWFYIQPTLRTMEVLASIATSLDKGECLGGATLSLLHDRTFGYTGDNQAQELCLYLT 379

  Fly   443 RKAAKPYMRMLQMWIQKGVIVDRHREFLVVDNEVIHRDELPEHYSDDYWERRYTLRDEQIPSFLA 507
            :.|:.||..:|:.||.:|:|.|.:.||:|.::| :.::::.|.|:|.||::|||:..:||||||.
Frog   380 KAASAPYFDILERWIYRGIINDPYSEFMVEEHE-LQKEKIQEDYNDKYWDQRYTIVQQQIPSFLQ 443

  Fly   508 KYSDKILRTGKYLNVIRQCGKRVMPTQEMNLEFDPTSERHVSVINDAYYFAARMLLDVLLTENDL 572
            |.:||||.|||||||:|:||..|.......:.:....:.:|..|..||.:|:::|||.|:.|.:|
Frog   444 KVADKILSTGKYLNVVRECGHDVTCPDAKEITYTLKEQAYVEQIEKAYNYASKVLLDFLMEEKEL 508

  Fly   573 MGHLQSVKRYLLLNQGDFTMQFMDACEDELTKNVDHVLPMTLENLLGLTLRISSARNDPYKDDLH 637
            :.||:|:|.|.|::||||.:.|||..|:||.|.|:.::|..||.||.|.||:|:|..||:||||.
Frog   509 VAHLRSIKHYFLMDQGDFFVHFMDLTEEELRKPVEDIIPTRLEALLELALRMSTANTDPFKDDLK 573

  Fly   638 CELLPYDLVTQMSKIMKKEENWQ-----AQP-RLDLSGLECFAFTYEVKWPCSLVLNHISISKYQ 696
            .||:|:||:||:.:::..|...:     |.| .|.|||||.|:|.|.||||.||::|..::::||
Frog   574 IELMPHDLITQLLRVLAIETRQEKALINADPTELALSGLESFSFDYIVKWPLSLIINRKALTRYQ 638

  Fly   697 MLFRQLFYCKHVERQLCKIWKENSIARQFEPQAASLYRAAFTLRQRMMNAIQNLEYYMMIEIIEP 761
            ||||.:||||||||.||.:|..|..|:||...:|..:..||||||||:|.:||::||||.|::||
Frog   639 MLFRHMFYCKHVERLLCNVWISNKTAKQFSLHSAKWFAGAFTLRQRMLNFVQNIQYYMMFEVMEP 703

  Fly   762 NWHIFIEKMKTVENVDNVLRLHQDFLDSCLKNCMLTESSHLNRSIF-KLCKICLKYCEFIQ-ITQ 824
            .|||..:.:|:..|:|:||..|..|||:|||:||||....|  .|| ||..:|:.:...:| .||
Frog   704 TWHILEKNLKSASNIDDVLSHHTSFLDNCLKDCMLTNPELL--KIFSKLMSVCVMFTNCLQRFTQ 766

  Fly   825 RYFQDAELRSMVRDSAD----------SSESEQESLHCPQIETPLDPTDT---FSERVRRFDLEF 876
            ......|:.::..:...          :.|:.::.|.....|..:|...:   |...:..||:.|
Frog   767 SMQVQTEMENLTLEHGTMMGPPTQCERTEEALKKKLTSKYFEEHIDAFPSSFGFESTINNFDINF 831

  Fly   877 TQLLISFLKQINSMAKKNTADC---FMNLVHRINFNAFYTDQMDKMCVE 922
            :..|:..|   :.::..:|:||   .:|:::|::||.|||:::.::..|
Frog   832 SAHLMDLL---DKLSMYSTSDCEHSMINIIYRLDFNGFYTERLKQLSSE 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip84	NP_728264.1	Spc97_Spc98	278..795	CDD:282045	214/524 (41%)
tubgcp2	XP_002940353.2	GCP_N_terminal	217..505	CDD:407574	97/294 (33%)
tubgcp2	XP_002940353.2	Spc97_Spc98	508..867	CDD:398000	147/363 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1590
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55980
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1441
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D124154at33208
OrthoFinder	1	1.000	-	-		FOG0005184
OrthoInspector	1	1.000	-	-		oto103579
Panther	1	1.100	-	-	LDO	PTHR19302
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160