Protein Alignment CG32532 and ESX1

DIOPT Version :10

• Sequence 1: NP_608318.5
• Gene: CG32532 / 32943
• FlyBaseID: FBgn0052532
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_703149.1
• Gene: ESX1 / 80712
• HGNCID: 14865
• Length: 406
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 77/268 - (28%)
• Similarity: 105/268 - (39%)
• Gaps: 71/268 - (26%)

  Fly   361 VGQDTKFMSFQDQR-----LMGIGGSHENRLLSLASSVQDTRSPITTLEKSSSSSLNHQRKCSST 420
            ||:|.:  ...|::     ||..||..|          ::|||.    .:..:.:.|:.....|.
Human    19 VGEDIE--EVNDEKLTVTSLMARGGEDE----------ENTRSK----PEYGTEAENNVGTEGSV 67

  Fly   421 PEDFSALYSGLPTPGMDSSSHHHTPAHTPPSRLSDHTISAEGAFKKLKPEPNSGLSTVSAGITSP 485
            |.|......|   .|.:.......|..|.|.:..:     |....:||.|......|...| ..|
Human    68 PSDDQDREGG---GGHEPEQQQEEPPLTKPEQQQE-----EPPLLELKQEQEEPPQTTVEG-PQP 123

  Fly   486 GSGLSSLSQHAGHTPTTASCPTP--ARRRHRTTFTQEQLAELEAAFAKSHYPDIYCREELARTTK 548
            ..|           |.||..|.|  .:||.||.|||.||.|||..|.:|.|||:..||.||....
Human   124 AEG-----------PQTAEGPQPPERKRRRRTAFTQFQLQELENFFDESQYPDVVARERLAARLN 177

  Fly   549 LNEARIQVWFQNRRAKYRKQEKQLQKALAPSVIPSCNGMMRNIQGYSVSRGYQPYPHHNTMNRYP 613
            |.|.|:||||||||||:::.::.|              |:||.....::              :|
Human   178 LTEDRVQVWFQNRRAKWKRNQRVL--------------MLRNTATADLA--------------HP 214

  Fly   614 QDLFQMGA 621
            .|:|..||
Human   215 LDMFLGGA 222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32532	NP_608318.5	Homeodomain	511..567	CDD:459649	34/55 (62%)
ESX1	NP_703149.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..142		31/142 (22%)
		PLN02328	45..>148	CDD:215187	30/126 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	138..143		2/4 (50%)
		Homeodomain	140..196	CDD:459649	34/55 (62%)
		15 X 9 AA tandem repeats of P-P-x-x-P-x-P-P-x	244..378
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..364