DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32532 and Nanog

DIOPT Version :9

Sequence 1:NP_608318.5 Gene:CG32532 / 32943 FlyBaseID:FBgn0052532 Length:688 Species:Drosophila melanogaster
Sequence 2:NP_082292.1 Gene:Nanog / 71950 MGIID:1919200 Length:305 Species:Mus musculus


Alignment Length:340 Identity:85/340 - (25%)
Similarity:129/340 - (37%) Gaps:87/340 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   376 MGIGGSHENRLLSLASSVQDTRSPITTLEKSSSSSLNHQRKCSSTPEDFSALYSGLPTPGMDSSS 440
            :|:.|.|     ||.||.:.:.|.    ..||..::.|       ||::|.| .|..|..:    
Mouse     3 VGLPGPH-----SLPSSEEASNSG----NASSMPAVFH-------PENYSCL-QGSATEML---- 46

  Fly   441 HHHTPAHTPPSRLSDHTISAEGAFKKLKPEPNSGLSTVSAGITSPGSGLSSLSQHAGHTPTTASC 505
              .|.|.:|  |.|...:..:|:       |:|.        |||...|||.....|  |.....
Mouse    47 --CTEAASP--RPSSEDLPLQGS-------PDSS--------TSPKQKLSSPEADKG--PEEEEN 90

  Fly   506 PTPARR-RHRTTFTQEQLAELEAAFAKSHYPDIYCREELARTTKLNEARIQVWFQNRRAKYRKQE 569
            ...||: :.||.|:|.||..|:..|.|..|..:...:||:....|:..:::.||||:|.|.::.:
Mouse    91 KVLARKQKMRTVFSQAQLCALKDRFQKQKYLSLQQMQELSSILNLSYKQVKTWFQNQRMKCKRWQ 155

  Fly   570 KQ---------LQKALAPSVIPS--CN---GMMRNIQG--------------YSVSRGYQPYPHH 606
            |.         :||..||...||  |:   |.:.|..|              :|......|..::
Mouse   156 KNQWLKTSNGLIQKGSAPVEYPSIHCSYPQGYLVNASGSLSMWGSQTWTNPTWSSQTWTNPTWNN 220

  Fly   607 NTMNRYPQDLFQMGASSYPGMTQPFSMAHSTNMGSVGVRQDSMGEFHGMSPEDEWYNKSLSALRM 671
            .|............|.|:.|  ||::.|...|.|     :|.:..:..:.     .|.|.|.|.:
Mouse   221 QTWTNPTWSSQAWTAQSWNG--QPWNAAPLHNFG-----EDFLQPYVQLQ-----QNFSASDLEV 273

  Fly   672 N----SSHHPNLSAP 682
            |    ...|.:.|.|
Mouse   274 NLEATRESHAHFSTP 288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32532NP_608318.5 Homeobox 513..566 CDD:278475 19/52 (37%)
NanogNP_082292.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 10/35 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..95 16/73 (22%)
Sufficient for interaction with SALL4. /evidence=ECO:0000269|PubMed:16840789 96..155 19/58 (33%)
HOX 96..152 CDD:197696 19/55 (35%)
Required for DNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H9S0 123..152 9/28 (32%)
10 X repeats starting with a Trp in each unit 198..247 8/50 (16%)
Sufficient for transactivation activity 198..247 8/50 (16%)
Sufficient for strong transactivation activity 248..305 11/51 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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