Protein Alignment CG32532 and SHOX

DIOPT Version :10

• Sequence 1: NP_608318.5
• Gene: CG32532 / 32943
• FlyBaseID: FBgn0052532
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_000442.1
• Gene: SHOX / 6473
• HGNCID: 10853
• Length: 292
• Species: Homo sapiens
• Alignment Length: 279
• Identity: 83/279 - (29%)
• Similarity: 114/279 - (40%)
• Gaps: 84/279 - (30%)

  Fly   437 DSSSHHHTP--AHTPPSRLSDHTISAEGAFKKLKPEPNSGLSTVSAGI-----------TSPGSG 488
            |||....|.  .|.|.....||   .:...:|||   ..|.:.|:.||           :....|
Human    53 DSSLQDITEGGGHCPVHLFKDH---VDNDKEKLK---EFGTARVAEGIYECKEKREDVKSEDEDG 111

  Fly   489 LSSLSQHAGHTPTTASCPTPARRRHRTTFTQEQLAELEAAFAKSHYPDIYCREELARTTKLNEAR 553
            .:.|.|                ||.||.||.|||.|||..|.::||||.:.||||::...|:|||
Human   112 QTKLKQ----------------RRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEAR 160

  Fly   554 IQVWFQNRRAKYRKQEKQLQKAL---------APSVIPSCN-GMMR--------NIQGYSVSRGY 600
            :||||||||||.||||.|:.|.:         |..|.|..| |.:|        .:|...|:..:
Human   161 VQVWFQNRRAKCRKQENQMHKGVILGTANHLDACRVAPYVNMGALRMPFQQVQAQLQLEGVAHAH 225

  Fly   601 QPYPHHNTMNRYPQDLFQMGASSYPGMTQPF-----SMAHSTNMGSV---GVRQDSMGEFHGMSP 657
             |:.|.:.....|..:|.         ..||     |:|.|.:..:|   ..:.:|.
Human   226 -PHLHPHLAAHAPYLMFP---------PPPFGLPIASLAESASAAAVVAAAAKSNSK-------- 272

  Fly   658 EDEWYNKSLSALRMNSSHH 676
                 |.|::.||:.:..|
Human   273 -----NSSIADLRLKARKH 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32532	NP_608318.5	Homeodomain	511..567	CDD:459649	35/55 (64%)
SHOX	NP_000442.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..119		3/34 (9%)
		Homeodomain	118..174	CDD:459649	35/55 (64%)
		SH3-binding. /evidence=ECO:0000255	242..249		2/15 (13%)
		OAR	272..288	CDD:461067	5/28 (18%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	274..287		4/13 (31%)