Protein Alignment CG32532 and PITX2

DIOPT Version :10

• Sequence 1: NP_608318.5
• Gene: CG32532 / 32943
• FlyBaseID: FBgn0052532
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 99/332 - (29%)
• Similarity: 139/332 - (41%)
• Gaps: 80/332 - (24%)

  Fly   397 RSPITTLEKSSSSSLNHQRKCSSTPEDFSALYSGLPTPGMDSSSHHHTPAHTPPSRLSDHTISAE 461
            |:..|.|...||||.:|.:..:..    |.|..|.|. .:|||.|          ||..||||
Human    13 RAAGTKLSAVSSSSCHHPQPLAMA----SVLAPGQPR-SLDSSKH----------RLEVHTIS-- 60

  Fly   462 GAFKKLKPEPNSGLSTVSAGITSPGSGLSSLSQHAGHTPTTASCPTPAR--RRHRTTFTQEQLAE 524
                               ..:||.:.....||...:....|..|:..:  ||.||.||.:||.|
Human    61 -------------------DTSSPEAAEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQE 106

  Fly   525 LEAAFAKSHYPDIYCREELARTTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPSVI-PSCNGMM 588
            |||.|.::.|||:..|||:|..|.|.|||::|||:|||||:||:|:..|..|..:.. |..||:|
Human   107 LEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLM 171

  Fly   589 RNIQ----GY-----------SVSRGYQPYPHHNTMNRYP---QDLFQMGASSYPGMTQPFSMAH 635
            :...    ||           |.|...:.:|..|:||..|   |.:|. ..:|...|:...||..
Human   172 QPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFS-PPNSISSMSMSSSMVP 235

  Fly   636 STNMGSVGVRQDSMGEFHGMS----------------PEDEWY------NKSLSALRMNSSHHPN 678
            |...|..|...:|:...:.:|                |....|      |.||::||:.:..|.:
Human   236 SAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSS 300

  Fly   679 LSAPMLQ 685
            .....:|
Human   301 FGYASVQ 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32532	NP_608318.5	Homeodomain	511..567	CDD:459649	33/55 (60%)
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	33/55 (60%)
		OAR	282..299	CDD:461067	5/16 (31%)