DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32532 and Rx

DIOPT Version :9

Sequence 1:	NP_608318.5	Gene:	CG32532 / 32943	FlyBaseID:	FBgn0052532	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	821	Identity:	180/821 - (21%)
Similarity:	258/821 - (31%)	Gaps:	265/821 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RHKIRSIKTGARSPRDSFQLDYSIDFFKTYIDTQRFYAGH--------KLDFKHQSCAGGPGSGG 79
            ||.:.::       ||:..|...::.||........||.|        ..:..:..........|
  Fly    80 RHLLGNV-------RDAKNLQMIVEKFKNLEQFHEHYAAHLANNNTVISTEDSNDLVKDNARKYG 137

  Fly    80 AGGP------------------GPGGGGGASGVVVVGGTSNSNNPAAAQ---------------Q 111
            :||.                  |...|.|.:...|..|   |.:|:...               :
  Fly   138 SGGQTLTPRHTIDAILGLKNRNGAANGSGRNPETVSDG---SVDPSLGDDDATDLRCGMTLTQLR 199

  Fly   112 QQQQQQQQQQQQQQQSGG------NNPSNGSNSAV--ALSLAH--------PHA-HASHAHSSHA 159
            ..........||..::||      ..|..|....|  |..|.|        .|| ||.|.|.:|
  Fly   200 SMDNHMASMLQQHAKNGGALPYGPPTPPGGQQPQVPNATPLHHGQQMGGQAGHATHAGHGHPTH- 263

  Fly   160 HGSHA-----HALAIAHGHHGLLPSVVPQQQQQQQQQQQQQQQQQQAQQLPPGVGVASPL----- 214
            || ||     :|.....|.||     ....::..........|..:|.||..|...|:|.
  Fly   264 HG-HAPFGYHNAFGFGQGGHG-----YGHPEEAAGNYLNSMHQMVEANQLQTGANGANPPPAPLP 322

  Fly   215 -----QQQQQQQQQQQQQQQQQQQQQQLINNGGVSAGTP-----------TLLIGNGPSSSGAGT 263
                 ..||.......|.|:||.|..:...:....||.|           |..:  .||......
  Fly   323 PSSFGSHQQHLAALAAQAQEQQNQHSKYAKSSPTGAGPPPPPGAYFMESQTAPV--APSQINYDE 385

  Fly   264 GSVSAAAAAAA---AAAAASSSSSSLPHVAPHSLGLSPQSSADSQQFNIF-----PAIFSRQLNF 320
            .|:|:|:....   .||......:|.|..:|..     |.:|..:...:|     |.:
  Fly   386 RSMSSASDLEEDDDDAAKLQLDVTSPPTPSPRG-----QLAAKRKSAGVFCDDNEPKL------- 438

  Fly   321 SAGGQGGKLSMDELRPNLVGGLLGLQQGLLEDHASMQHGGVGQDTKFMSFQDQRLMGIGGSHENR 385
             |.||            |.||..|::...:|:....|.....|..:....|.|:|
  Fly   439 -ANGQ------------LPGGNYGIRPRSMEEVHHQQQSHHHQQQQQQQQQQQQL---------- 480

  Fly   386 LLSLASSVQDTRSPITTLEKSSSSSLNHQRKCSSTPEDFSALYSGLPTPGMDSSSHHHTPAHTPP 450
                                .......|         ||....:|.|....:|..|        .
  Fly   481 --------------------QQQQGFQH---------DFRNSGNGNPNGNSNSGDH--------G 508

  Fly   451 SRL---SDHTISAEGAFKKLKPEPNSGLSTVSAGITSPGSGLSSLSQHAGHTPTTASCPTPARRR 512
            .||   ||..::...|..:...:.||         :..|..::|.|...|...   :|.....||
  Fly   509 ERLNADSDSLVNGSCASSEDLNQTNS---------SEQGEKITSGSDDEGQDD---NCAKKKHRR 561

  Fly   513 HRTTFTQEQLAELEAAFAKSHYPDIYCREELARTTKLNEARIQVWFQNRRAKYRKQEKQ------ 571
            :|||||..||.|||.||.||||||:|.|||||....|.|.|:||||||||||:|:|||.
  Fly   562 NRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLG 626

  Fly   572 -------------------LQKALAPSVIPSCNGMMRNIQGYSVSRGYQPYP------------- 604
                               :...|:|.::.:..|.:.:.|  :|...|...|
  Fly   627 LTHFTQLPHRLGCGASGLPVDPWLSPPLLSALPGFLSHPQ--TVYPSYLTPPLSLAPGNLTMSSL 689

  Fly   605 ----HHNTMNRYPQDLFQMGASSYP---------GMTQPFSMAH-------STNMGSVGVRQDSM 649
                ||:..|..|......|....|         |:..|....|       |.::..:.....|:
  Fly   690 AAMGHHHAHNGPPPPHVGHGGHGQPQPPPPPPPHGVPHPHGSHHVVPLSHLSPHLSRMSPHATSL 754

  Fly   650 GE-FHGMSPEDEWYNKSL------SALRMNSSHHPNLSAPM 683
            |. .||::|.....:.||      :.:.::||...:.||.:
  Fly   755 GSPHHGVTPLGTPLHSSLPPSSTATTVAVSSSQSSSSSASL 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32532	NP_608318.5	Homeobox	513..566	CDD:278475	37/52 (71%)
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	37/51 (73%)
Rx	NP_726006.3	OAR	876..892	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010