DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32532 and HOXB3

DIOPT Version :9

Sequence 1:	NP_608318.5	Gene:	CG32532 / 32943	FlyBaseID:	FBgn0052532	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	XP_016880049.1	Gene:	HOXB3 / 3213	HGNCID:	5114	Length:	578	Species:	Homo sapiens

Alignment Length:	518	Identity:	126/518 - (24%)
Similarity:	169/518 - (32%)	Gaps:	143/518 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 GGVSAGTPTLL----IGNG-----PSSSGAGTGSVSAAAAAAAAAAAASSSSSSLPHVAPHSLG- 295
            ||...|...||    :|.|     ..|.|.|:|:..:|.|.....||.....   |...||..|
Human    98 GGTLGGCWGLLRVERLGCGWLRRRSPSLGRGSGAWQSAPARTQRPAARRCPR---PSGRPHRRGD 159

  Fly   296 LSP--QSSADSQQFNIFPAIFSRQLNFSAGGQGGKLSMDELRPNLVGGLLGLQQGLLEDHASMQH 358
            |||  :|.|..:.....|.:                      |:.|.             .:..|
Human   160 LSPAARSGARCEYILCLPVL----------------------PSSVA-------------KAATH 189

  Fly   359 GGVGQDTKFMSFQDQRLMGIGGSHENRLLSLASSVQDTRSPITTLEKSSSSSLNHQ-RKCSSTPE 422
                               :.|.::....||.|  ....:|     .:.|..||.. .:....||
Human   190 -------------------LEGDYQRSACSLQS--LGNAAP-----HAKSKELNGSCMRPGLAPE 228

  Fly   423 DFSA-----LYSGLPTPGMDSSSHHHTPAHTPPSRLSDHTISA--------------EGAFKKLK 468
            ..||     ..|..||....:||:...|:.:.|.:....|.|.              ....|...
Human   229 PLSAPPGSPPPSAAPTSATSNSSNGGGPSKSGPPKCGPGTNSTLTKQIFPWMKESRQTSKLKNNS 293

  Fly   469 PEPNSGLSTVSAGITSPGSGLSSLSQHAGHTPTTASCPTPARRRHRTTFTQEQLAELEAAFAKSH 533
            |....|......|....|||.|......|.....:...:.|.:|.||.:|..||.|||..|   |
Human   294 PGTAEGCGGGGGGGGGGGSGGSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEF---H 355

  Fly   534 YPDIYCRE---ELARTTKLNEARIQVWFQNRRAKYRKQEKQLQKALA------------PSVIPS 583
            :....||.   |:|....|:|.:|::||||||.||:|.:|  .|.||            |..:.|
Human   356 FNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKYKKDQK--AKGLASSSGGPSPAGSPPQPMQS 418

  Fly   584 CNGMMRNIQGYSVSRGYQ-PYP------HHNTM---NRYPQDLFQMGA-SSYPGMTQPFSMAH-- 635
            ..|.|..:  :|::..|: |.|      |.|..   :.|...|...|| ..||....|....|
Human   419 TAGFMNAL--HSMTPSYESPSPPAFGKAHQNAYALPSNYQPPLKGCGAPQKYPPTPAPEYEPHVL 481

  Fly   636 STNMGSVG--VRQDS---MGEFHGMSPEDEWYNKSLSALRMNSSHHP------NLSAPMLQYQ 687
            ..|.|:.|  ..|.|   :|......|.......||..|. :.||||      |.:.||...|
Human   482 QANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLN-HLSHHPSGNLDYNGAPPMAPSQ 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32532	NP_608318.5	Homeobox	513..566	CDD:278475	24/55 (44%)
HOXB3	XP_016880049.1	Homeobox	339..391	CDD:278475	24/54 (44%)
HOXB3	XP_016880049.1	DUF4074	513..576	CDD:290032	11/32 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910