DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32532 and HOXA3

DIOPT Version :9

Sequence 1:	NP_608318.5	Gene:	CG32532 / 32943	FlyBaseID:	FBgn0052532	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_001371264.1	Gene:	HOXA3 / 3200	HGNCID:	5104	Length:	443	Species:	Homo sapiens

Alignment Length:	409	Identity:	91/409 - (22%)
Similarity:	141/409 - (34%)	Gaps:	116/409 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 LQQGLLEDHASMQHG-------GVGQDTKFMSFQDQRLMGIGGSHENRLLSLASSVQDTRSPITT 402
            :|:....|.:::..|       |...:.....:.....:|..|.:.....||
Human     1 MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSL------------- 52

  Fly   403 LEKSSSSSLNHQRKCSSTPEDFSALYSGLPTPGMDSSSHHHTPAHTPPSRLSDHTISAEGAFKKL 467
              :|.||:..|.:    ..|...|....|..|.....|....|.|.||.:      :|..|.:..
Human    53 --QSPSSAGGHPK----AHELSEACLRTLSAPPSQPPSLGEPPLHPPPPQ------AAPPAPQPP 105

  Fly   468 KPEPNSGLSTVSAGITSPGSGLSSLSQHAGHTPTTASC--------PTPAR-------------- 510
            :|.|.....|.:|   .|....:|..|:|.:.||.|:.        ||.|:
Human   106 QPAPQPPAPTPAA---PPPPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTK 167

  Fly   511 ------------------------RRHRTTFTQEQLAELEAAFAKSHYPDIYCRE---ELARTTK 548
                                    :|.||.:|..||.|||..|   |:....||.   |:|....
Human   168 QKTSSSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEF---HFNRYLCRPRRVEMANLLN 229

  Fly   549 LNEARIQVWFQNRRAKYRKQEKQLQKAL-------APS---VIPSCNGMMRNIQGYSVSRGYQPY 603
            |.|.:|::||||||.||:|.:|  .|.:       :||   |.|...|.:.::.....|..|:|.
Human   230 LTERQIKIWFQNRRMKYKKDQK--GKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQ 292

  Fly   604 --PHHNTMNRYPQDLFQMGASSYPGMTQPFSMAHSTNMGSVGVRQDSMGEFHGMSPEDEWYNKSL 666
              |   ..::.||..:.:..:|||.     |:...........|..:.|...|.:|:   |:...
Human   293 SPP---PFSKPPQGTYGLPPASYPA-----SLPSCAPPPPPQKRYTAAGAGAGGTPD---YDPHA 346

  Fly   667 SALRMNSSHHPNLSAPMLQ 685
            ..|:.|.|:    ..|.:|
Human   347 HGLQGNGSY----GTPHIQ 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32532	NP_608318.5	Homeobox	513..566	CDD:278475	24/55 (44%)
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..147		20/80 (25%)
		Antp-type hexapeptide	155..160		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..196		1/36 (3%)
		Homeobox	195..248	CDD:395001	25/55 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..338		20/100 (20%)
		DUF4074	378..441	CDD:404218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910