DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CoRest and Mier1

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_030109639.1	Gene:	Mier1 / 71148	MGIID:	1918398	Length:	626	Species:	Mus musculus

Alignment Length:	424	Identity:	92/424 - (21%)
Similarity:	146/424 - (34%)	Gaps:	110/424 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 NNSGHSGNANANEKTTTAVPGAGTPESSDDDNSTK------------RNGKSKAKQSEYEE---- 90
            :|||.||. |..|....:.......:||:||.|..            |..|.....||.||
Mouse   219 DNSGCSGE-NKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSEIEEESEE 282

  Fly    91 ------------KIRVGRDYQAVCPPLVPEAERRPEQMNERALLVWSPTKEIPDLKLEEYISVAK 143
                        :|.||..:||..|..|...:...:.......|:|.| :.:|:.|:..::..|.
Mouse   283 DEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDP-ECLPEEKVVVFLKDAS 346

  Fly   144 EKYG--------------YNGEQALGMLFWHKHDLERAVMDLA-NFTPFPDE---WTIEDKVLFE 190
            .:.|              .:.||||..|.....|.|.|:..|. |.....:|   ||.|:...||
Mouse   347 RRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFNVKAAREELSVWTEEECRNFE 411

  Fly   191 QAFQFHGKSFHRIR-QMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVVKDGSENGSEVG 254
            |..:.:||.||.|: ..:..:|:...|.:||.|||: .|.....:|.:.
Mouse   412 QGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKS-ERYDFFAQQTRF---------------- 459

  Fly   255 SNEESDNDDKKGHGTNSTINTIDATTTSTNNSTTNSNTTTPANIIANTINS------------NH 307
                    .||.:..:..:..........:.|..:|...:|....:|:.||            |.
Mouse   460 --------GKKKYNLHPGVTDYMDRLLDESESAASSRAPSPPPTASNSSNSQSEKEDGAVSSRNQ 516

  Fly   308 SSSNSGGGGNINNNGEENIQAV------GGSN--TISNTSNNDMDAEQLSLFAGNAQIEEMMALG 364
            :..:|.|.|.|.|..|..::.:      ||:.  .:::...|..:|..|:.   :.::..|.|
Mouse   517 NGVSSNGPGEILNKEEVKVEGLHVNGPTGGNKKPLLTDMDTNGYEANNLTT---DPKLAHMTA-- 576

  Fly   365 LAADRAIGANGGNNNNNGEMGGDPGLMRRMVVGG 398
                       .|.|:..|....|...||:...|
Mouse   577 -----------RNENDFDEKNERPAKRRRINSSG 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	13/51 (25%)
		SANT	179..225	CDD:197842	18/49 (37%)
		SANT	180..224	CDD:304392	17/47 (36%)
		SANT	540..582	CDD:238096
Mier1	XP_030109639.1	ELM2	296..346	CDD:366648	12/50 (24%)
Mier1	XP_030109639.1	SANT_MTA3_like	402..446	CDD:212559	16/43 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810