DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CoRest and Zfp541

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001092747.1	Gene:	Zfp541 / 666528	MGIID:	3647699	Length:	1363	Species:	Mus musculus

Alignment Length:	234	Identity:	67/234 - (28%)
Similarity:	93/234 - (39%)	Gaps:	64/234 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 EEKIRVGRDYQAVCPPLVPEAERRPEQMNER-ALLVWSPTKEI---PDL--KLEEYISVAKEKY- 146
            |..|.||..:||..|.|   .||...:::|. |.|||.|..::   |:.  ::.|..:||....
Mouse  1062 EPHINVGSRFQAEIPEL---QERLLARVDENVASLVWKPWGDVMTNPETQDRVMELCNVACSSVM 1123

  Fly   147 ---GYNGEQALGMLFWHKHDLERAVM-----------------DLANFT-PFPDEWTIEDKVLFE 190
               |.|.|.||..|    ||.:.:|.                 .||::. ...|.||..:|.||:
Mouse  1124 PGGGTNLELALHCL----HDAQGSVQVALETLLLRGPQKPRTHPLADYRYTGSDIWTPMEKRLFK 1184

  Fly   191 QAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVVK--DGSENGSEV 253
            :||..|.|.|:.|.:|:..||:|..|:|||.|||                 :||  .|...|.|.
Mouse  1185 KAFCAHKKDFYLIHKMIQTKSVAQCVEYYYIWKK-----------------MVKFDCGRAPGLEK 1232

  Fly   254 GSNEESDNDDKKGHGTNSTINTIDATTTSTNNSTTNSNT 292
            ....|.|..::          |.|..|.|.....|:..|
Mouse  1233 RGRRELDEVER----------TEDKVTCSPRERPTHRPT 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	19/57 (33%)
		SANT	179..225	CDD:197842	22/45 (49%)
		SANT	180..224	CDD:304392	20/43 (47%)
		SANT	540..582	CDD:238096
Zfp541	NP_001092747.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		COG5236	<80..>329	CDD:227561
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..137
		C2H2 Zn finger	142..162	CDD:275368
		zf-C2H2	142..162	CDD:278523
		zf-H2C2_2	154..179	CDD:290200
		zf-C2H2_6	168..192	CDD:290623
		C2H2 Zn finger	170..190	CDD:275368
		C2H2 Zn finger	198..216	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..269
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..387
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	440..532
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..741
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	935..978
		ELM2	1065..1120	CDD:279754	19/57 (33%)
		SANT	1175..1219	CDD:197842	22/60 (37%)
		SANT	1175..1218	CDD:304392	20/42 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1243..1298		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1343..1363
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810