DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CoRest and MIER1

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001337459.1	Gene:	MIER1 / 57708	HGNCID:	29657	Length:	602	Species:	Homo sapiens

Alignment Length:	428	Identity:	95/428 - (22%)
Similarity:	146/428 - (34%)	Gaps:	125/428 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 NNSGHSGNANANEKTTTAVPGAGTPESSDDDNSTK------------RNGKSKAKQSEYEEKIRV 94
            :|||.||. |..|....:.......:||:||.|..            |..|.....||.||:...
Human   195 DNSGCSGE-NKEENIKDSSGQEDETQSSNDDPSQSVASQDAQEIIRPRRCKYFDTNSEVEEESEE 258

  Fly    95 GRDYQAVCPPLVPEAERRPEQM------------------NERAL-----LVWSPTKEIPDLKLE 136
            ..||       :|..:.:.|.|                  ||:..     |:|.| :.:|:.|:.
Human   259 DEDY-------IPSEDWKKEIMVGSMFQAEIPVGICRYKENEKVYENDDQLLWDP-EYLPEDKVI 315

  Fly   137 EYISVAKEKYG--------------YNGEQALGMLFWHKHDLERAVMDLA-NFTPFPDE---WTI 183
            .::..|..:.|              .:.||||..|.....|.|.|:..|. |.....:|   ||.
Human   316 IFLKDASRRTGDEKGVEAIPEGSHIKDNEQALYELVKCNFDTEEALRRLRFNVKAAREELSVWTE 380

  Fly   184 EDKVLFEQAFQFHGKSFHRIR-QMLPDKSIASLVKYYYSWKK----------------------- 224
            |:...|||..:.:||.||.|: ..:..:|:...|.:||.|||
Human   381 EECRNFEQGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPG 445

  Fly   225 -TRHRSSAMDRQEKAIKAVVKDGSENGSEVGSNEESDNDDKKGHGTNSTINTIDATTTSTNNSTT 288
             |.:....:|..|.|..:.........|. .||.:|:.:|    ||.||.|        .|..::
Human   446 VTDYMDRLLDESESAASSRAPSPPPTASN-SSNSQSEKED----GTVSTAN--------QNGVSS 497

  Fly   289 NSNTTTPANIIAN---TINSNHSSSNSGGG-----GNINNNGEENIQAVGGSNTISNTSNNDMDA 345
            |.    |..|:..   .:...|.:..:||.     .:::.||.|.............|:.|:.|.
Human   498 NG----PGEILNKEEVKVEGLHINGPTGGNKKPLHADMDTNGYETDNLTTDPKLAHMTARNENDF 558

  Fly   346 EQLSLFAGNAQIEEMMALGLAADRAIGANGGNNNNNGE 383
            ::.|        |..     |..|.:.:||..:..:.|
Human   559 DEKS--------ERP-----AKRRRVNSNGKESPGSSE 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	13/74 (18%)
		SANT	179..225	CDD:197842	19/73 (26%)
		SANT	180..224	CDD:304392	17/47 (36%)
		SANT	540..582	CDD:238096
MIER1	NP_001337459.1	ELM2	272..321	CDD:307553	8/49 (16%)
MIER1	NP_001337459.1	SANT_MTA3_like	378..422	CDD:212559	16/43 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810