DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CoRest and rcor1

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001073510.1	Gene:	rcor1 / 569294	ZFINID:	ZDB-GENE-050506-79	Length:	458	Species:	Danio rerio

Alignment Length:	655	Identity:	197/655 - (30%)
Similarity:	298/655 - (45%)	Gaps:	206/655 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LAERNTTDVVRNGRRSRGPSPNTHTTGGVTNSASLVGSGNNSGHSGNANANEKTTTAVPGAGTPE 67
            :.|:.||::  :|:|....|.|..|....:|     |:.|||...|::.:
Zfish     4 MLEKGTTEI--SGKRRGRNSVNNPTKSFTSN-----GNSNNSWEEGSSGS--------------- 46

  Fly    68 SSDDDNSTKRNGKSKAKQSEYEEKIRVGRDYQAVCPPLVPEAERRPEQMNERALLVWSPTKEIPD 132
            ||||::..  .|            :|||..||||.|...||..:...:.....:|||.|...||:
Zfish    47 SSDDEHGA--GG------------MRVGPQYQAVVPDYDPEVAKASHERENLGMLVWIPKTSIPE 97

  Fly   133 LKLEEYISVAKEKYGYNGEQALGMLFWHKHDLERAVMDLANFTPFPDEWTIEDKVLFEQAFQFHG 197
            .||:|||::||||:|||.||||||||||||::|:::.||.||||||||||:||||||||.|.|||
Zfish    98 AKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQGFSFHG 162

  Fly   198 KSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVVKDGSENGSEVGSNEESDND 262
            |:||||:||||||||||||::||||||||.::|.|||..:..|.             ..||||.:
Zfish   163 KTFHRIQQMLPDKSIASLVRFYYSWKKTRSKTSVMDRHARKQKR-------------EREESDEE 214

  Fly   263 DKKGHGTNSTINTIDATTTSTNNSTTNSNTTTPANIIANTINSNHSSSNSGGGGNINNNGEENIQ 327
            ::.|                                           |.|.|...:..|.||..:
Zfish   215 EENG-------------------------------------------STSPGDTELEPNKEEKKE 236

  Fly   328 AVGGSNTISNTSNNDMDAEQLSLFAGNAQIEEMMALGLAADRAIGANGGNNNNNGEMGGDPGLMR 392
            ...|:.                                                 :....|.:::
Zfish   237 GTSGTE-------------------------------------------------KQESKPAVVQ 252

  Fly   393 RMVVGGFCKICNVVCHVLHDSPLGRMCKSCHTHWRRTGNRRPISGPEGNAPRRSTHNCAATADRS 457
            :..             :|.:.|:         |.::..        :|.|.|        ..:|:
Zfish   253 KPA-------------ILAEKPM---------HVKKEA--------QGLAGR--------NLNRA 279

  Fly   458 KRKPPKGMYINHDDLTALASCGNPSL-YLAERERKLTALMAEIQKNRQVMEQLDKECETINVDDV 521
            |:|||||||::.||:||::|.|..:: .|...:.:|.|:..:||..:|....|.::.:| .||:.
Zfish   280 KKKPPKGMYLSADDVTAMSSSGPAAVSVLRGLDMELIAIKRQIQSIKQHNSALREKLDT-GVDEF 343

  Fly   522 LSKPAAANTESAQPRISARWLPDEIQVALLAIREYGKNFPTIAKVVATKTEAHVRTFYLNNRRRY 586
              :|:.:|     .:.:.||..:|..:|:.|||:||::|..|:.|:..|:...|:.|::|.|||:
Zfish   344 --RPSESN-----QKFNTRWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRF 401

  Fly   587 NLDQIVKEYEA--GKSEESGAEEQTEPAVDAAAAGAATASAPSAADSTSAASATADRKQST--EN 647
            |||::::|:||  |..|..|.:|:....              |:.|.|::..|....::.|  |.
Zfish   402 NLDEVLQEWEAEHGVEERKGLDEEKMEV--------------SSEDGTTSGPAENQTEEQTPMET 452

  Fly   648 SNNGV 652
            .|..|
Zfish   453 QNPSV 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	22/51 (43%)
		SANT	179..225	CDD:197842	38/45 (84%)
		SANT	180..224	CDD:304392	36/43 (84%)
		SANT	540..582	CDD:238096	15/41 (37%)
rcor1	NP_001073510.1	ELM2	57..109	CDD:279754	22/51 (43%)
		SANT	144..190	CDD:197842	38/45 (84%)
		SANT	145..189	CDD:304392	36/43 (84%)
		SANT	354..400	CDD:197842	17/45 (38%)
		Myb_DNA-binding	355..398	CDD:278669	16/42 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32246
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2733
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287298at33208
OrthoFinder	1	1.000	-	-		FOG0001182
OrthoInspector	1	1.000	-	-		otm25130
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3377
SonicParanoid	1	1.000	-	-		X1336
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.960