DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CoRest and mier3b

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_005166936.1	Gene:	mier3b / 567247	ZFINID:	ZDB-GENE-070424-65	Length:	538	Species:	Danio rerio

Alignment Length:	402	Identity:	88/402 - (21%)
Similarity:	153/402 - (38%)	Gaps:	99/402 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 EKTTTA----VPGAGTPESSDDDNSTKRNGKS--KAKQSEYEE----------KIRVGRDYQAVC 102
            |:|.::    .|...:.|::|....|.|:..:  ..|:||.||          :|.||..|||..
Zfish   119 EETQSSADDLTPSVTSHEATDFFPRTLRSNVTYDGDKESEGEEDGVNSEDSRKEIMVGSQYQAEV 183

  Fly   103 PPLVPEAERRPEQMNERALLVWSPTKEIPDLKLEEYISVA-----KEKYGY-------NGEQALG 155
            |..:.......:...|...|:|.| .|:.:.|:::|:..|     .::..|       :.||||.
Zfish   184 PAGLSHYNDDEKVYEEEDQLLWCP-DELSEYKVKDYLREALSQSTDDRTHYSTSEHIRDNEQALF 247

  Fly   156 MLFWHKHDLERA-VMDLANFTPFPDE---WTIEDKVLFEQAFQFHGKSFHRI-RQMLPDKSIASL 215
            .|....:|...| |...:|.....:|   |:.|:...||.|.|.:.|:||.| :..:..:::|..
Zfish   248 ELLKCNYDTREALVRYCSNVKTSKEESPPWSEEECRNFEHALQIYEKNFHLIQKHKVQTRTVAEC 312

  Fly   216 VKYYYSWKKT--------RHR------------SSAMDRQEKAIKAVVKDGSEN--GSEVGSNEE 258
            |.:||.|||:        ::|            :..|||.....:.:..|||..  .:..|...|
Zfish   313 VAFYYMWKKSERFDYFAQQNRFGKKKYSCYPGVTDLMDRLVDEAEGLAVDGSSPVCSAGAGGRLE 377

  Fly   259 SDNDDKKGHGTNSTINTIDATTTSTNNSTTNSNTTTPANIIANTINS------------------ 305
            :..:.:.|                ..||.|.|:.|..:|.:||..|.
Zfish   378 ASAEQQLG----------------LLNSITASDLTALSNSVANVCNGPAEMSCLDSPFFPPLESL 426

  Fly   306 -----NH----SSSNSGGGGNINNNGEENIQAVGGSNTISNTSNNDMDAEQLSLFAGNAQIEEMM 361
                 ||    |...:|.|..:|.......::..|..::.::.:.:..:::|.:....:.|.::.
Zfish   427 HRAALNHDDQLSYGTNGDGVCLNMLDSGFYRSDLGQLSMCSSKDCERPSKRLKMGLSESFINDVD 491

  Fly   362 ALGLAADRAIGA 373
            ..|..|.|..||
Zfish   492 FEGRRAHRITGA 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	15/56 (27%)
		SANT	179..225	CDD:197842	17/49 (35%)
		SANT	180..224	CDD:304392	16/47 (34%)
		SANT	540..582	CDD:238096
mier3b	XP_005166936.1	ELM2	173..224	CDD:279754	15/51 (29%)
mier3b	XP_005166936.1	SANT	282..321	CDD:304392	13/38 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810