DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CoRest and mier1b

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001278272.1	Gene:	mier1b / 566167	ZFINID:	ZDB-GENE-070705-170	Length:	494	Species:	Danio rerio

Alignment Length:	459	Identity:	102/459 - (22%)
Similarity:	173/459 - (37%)	Gaps:	123/459 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AERNTTDVVR----NGRRSRGPSPNTHTTGG------VTNSASLVGSGNNSGHSGNANANEKTTT 58
            :.|:|.|:.:    ..:.|.|....:|:|..      ..|.|.|:.: .|.|:..|...:|
Zfish   103 SSRSTGDLKKRQEDGAKVSTGIVKESHSTDSRACAVKACNKAELIRT-KNHGYFQNNEVDE---- 162

  Fly    59 AVPGAGTPESSDDDNSTKRNGKSKAKQSEYEEKIRVGRDYQAVCPP-LVPEAERRPEQMNERALL 122
                    ||.:||:        .....:::::|.||..|||..|. |....|......|:..||
Zfish   163 --------ESEEDDD--------YIPSEDWKKEIMVGSMYQAETPSGLCKYKENEKVYENDDQLL 211

  Fly   123 VWSPTKEIPDLKLEEYISVAKEKYG-YNGEQAL--GMLFWHKHDLERAVMDLANFTPFPDE---- 180
             |:| :.:|:..:.|:::.|..:.| ..|..|:  |.   |..|.|:|:.:|.......||
Zfish   212 -WNP-QMLPENTVVEFLTDACRRTGEETGVDAIPEGS---HIKDNEQALYELVKCNFETDEALRR 271

  Fly   181 --------------WTIEDKVLFEQAFQFHGKSFHRIR-QMLPDKSIASLVKYYYSWKKTRHRSS 230
                          ||.|:...|||..:.:||.||.|: ..:..:|:...|.:||.|||: .|..
Zfish   272 LRFNVKAAREELSVWTEEECRNFEQGLKAYGKDFHFIQANKVRTRSVGDCVAFYYMWKKS-ERYD 335

  Fly   231 AMDRQEKAIKAVVKDGSENGSEVGSNEESDN--DDKKGHGTNSTINTIDATTTSTNNSTTNSNTT 293
            ...:|.:..|      .:.....|..:..|.  |:.:...::.....:.|.::|:..|.:....|
Zfish   336 FFAQQTRLGK------RKYNLHPGVTDYMDRLLDETESTASSRAATPLPAASSSSTTSQSEREET 394

  Fly   294 TPANIIANTINSNHSSSNSGGGGNINNNGE---ENIQAVGGSNTISNTSNNDMDAEQLSLFAGNA 355
            :..|.:     |:|||| :.|...::::.|   |::||.|....:.:|.:.|.:..:|:
Zfish   395 SGHNGL-----SSHSSS-ADGIQTLSSDNEVKIESVQANGAPKHLLHTDHTDSNGVKLT------ 447

  Fly   356 QIEEMMALGLAADRAIGANGGNNNNNGEMGGDPGLMRRMVVGGFCKICNVVCHVLHDSPLGRMCK 420
            :|.                  |.|.||                      .|.|.|....|.|..|
Zfish   448 EIH------------------NTNRNG----------------------AVKHQLDCQSLERPAK 472

  Fly   421 SCHT 424
            .|.|
Zfish   473 KCRT 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	17/52 (33%)
		SANT	179..225	CDD:197842	19/64 (30%)
		SANT	180..224	CDD:304392	17/62 (27%)
		SANT	540..582	CDD:238096
mier1b	NP_001278272.1	ELM2	180..230	CDD:279754	16/51 (31%)
		SANT	286..331	CDD:197842	17/44 (39%)
		SANT_MTA3_like	286..330	CDD:212559	16/43 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810