Protein Alignment CoRest and RCOR3

DIOPT Version :10

• Sequence 1: NP_001188671.1
• Gene: CoRest / 32941
• FlyBaseID: FBgn0261573
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_001336998.1
• Gene: RCOR3 / 55758
• HGNCID: 25594
• Length: 585
• Species: Homo sapiens
• Alignment Length: 689
• Identity: 200/689 - (29%)
• Similarity: 289/689 - (41%)
• Gaps: 240/689 - (34%)

  Fly    15 GRRSRGP---SPNTHTTGGVTNSASLVGSGNNSGHSGNANANEKTTTAVPGAGTPESSDDDNSTK 76
            |...:||   ..|....|...:.|...|||.:| .:|..:.:|      |.:|.  ||||
Human     3 GMMEKGPELLGKNRSANGSAKSPAGGGGSGASS-TNGGLHYSE------PESGC--SSDD----- 53

  Fly    77 RNGKSKAKQSEYEEKIRVGRDYQAVCPPLVPEAERR----------------PEQMNERA----- 120
                      |::..:|||.:|||..|...|...|.                |...::.|
Human    54 ----------EHDVGMRVGAEYQARIPEFDPVETRSCYVSQAGLKLRGSSHPPSLASQSAGIIGA 108

  Fly   121 ----------LLVWSPTKEIPDLKLEEYISVAKEKYGYNGEQALGMLFWHKHDLERAVMDLANFT 175
                      :|||||...|||.||:|||::||||:|||.||||||||||||::|:::.||.|||
Human   109 TKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFT 173

  Fly   176 PFPDEWTIEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIK 240
            |||||||:||||||||||.|||||||||:||||||:|||||||||||||||.|:|.||||.:.:
Human   174 PFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKL- 237

  Fly   241 AVVKDGSENGSEVGSNEESDNDDKKGHGTNSTINTIDATTTSTNNSTTNSNTTTPANIIANTINS 305
                        ...:.:.|:||             |...|                   :.::.
Human   238 ------------ANRHNQGDSDD-------------DVEET-------------------HPMDG 258

  Fly   306 NHSSSNSGGGGNINNNGEENIQAVGGSNTISNTSNNDMDAEQLSLFAGNAQIEEMMALGLAADRA 370
            |.|..:.........|.|:.:|          ||         .:..|..:.:.:.
Human   259 NDSDYDPKKEAKKEGNTEQPVQ----------TS---------KIGLGRREYQSLQ--------- 295

  Fly   371 IGANGGNNNNNGEMGGDPGLMRRMVVGGFCKICNVVCHVLHDSPLGRMCKSCHTHWRRTGNRRPI 435
                                                                |.|
Human   296 ----------------------------------------------------HRH---------- 298

  Fly   436 SGPEGNAPRRSTHNCAATADRSKRKPPKGMYINHDDLTALASCGN-PSLYLAERERKLTALMAEI 499
                        |     :.|||.:||||||:..:|:.|::...| .:..|.:.:.:|.:|..::
Human   299 ------------H-----SQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQV 346

  Fly   500 QKNRQVMEQLDKECETINVDDVLSKPAAANTESAQPRISARWLPDEIQVALLAIREYGKNFPTIA 564
            |..:||...|.::.|. .:::.  ||..:|     .:|:|||..:|..:|:..:|:|||:|..||
Human   347 QNAKQVNSALKQKMEG-GIEEF--KPPESN-----QKINARWTTEEQLLAVQGVRKYGKDFQAIA 403

  Fly   565 KVVATKTEAHVRTFYLNNRRRYNLDQIVKEYEAGKSEESGAEEQTEPAVDAAAAGAATASAPSAA 629
            .|:..||...|:.|::|.|||:||:::::|:||    |.|.:             |:...|.:..
Human   404 DVIGNKTVGQVKNFFVNYRRRFNLEEVLQEWEA----EQGTQ-------------ASNGDASTLG 451

  Fly   630 DSTSAASATADRKQSTENSNNGVETMQESLPKKEDPKKP 668
            :.|.:||.....|.:.|..    |......|:...|..|
Human   452 EETKSASNVPSGKSTDEEE----EAQTPQAPRTLGPSPP 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:460214	25/82 (30%)
		SANT	180..224	CDD:473887	39/43 (91%)
		Myb_DNA-binding	540..583	CDD:459731	17/42 (40%)
RCOR3	NP_001336998.1	ELM2	59..142	CDD:460214	25/82 (30%)
		SANT	178..222	CDD:473887	39/43 (91%)
		Myb_DNA-binding	379..422	CDD:459731	17/42 (40%)