DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CoRest and MIER2

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001374081.1	Gene:	MIER2 / 54531	HGNCID:	29210	Length:	547	Species:	Homo sapiens

Alignment Length:	285	Identity:	70/285 - (24%)
Similarity:	118/285 - (41%)	Gaps:	44/285 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ERNTTDVVRNGRRSRGPSPNTHTTGGVTNSASLVGSGNNSGHSGNANANEKTTTAVPGAGTPESS 69
            |:...|::.........|.....|..||:..:.....|.||....|:.:.:     ||:..  ||
Human   126 EQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPNRSGSRFLADEDRE-----PGSSA--SS 183

  Fly    70 DDDNSTKRNGKSKAKQSEYEEKIRVGRDYQAVCPPLVPEAERRPEQM--NERALLVWSPTKEIPD 132
            |.:..:....|.|       ::|.||..:||....|  ...|..|::  ||..|| |.|: .:|:
Human   184 DTEEDSLPANKCK-------KEIMVGPQFQADLSNL--HLNRHCEKIYENEDQLL-WDPS-VLPE 237

  Fly   133 LKLEEYISVAKEKYGY--------------NGEQALGMLFWHKHDLERAVMDLA-NFTPFPD--- 179
            .::||::..|.::..:              :.||||..|.....::|.|:..|. |.....|
Human   238 REVEEFLYRAVKRRWHEMAGPQLPEGEAVKDSEQALYELVKCNFNVEEALRRLRFNVKVIRDGLC 302

  Fly   180 EWTIEDKVLFEQAFQFHGKSFHRIR-QMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVV 243
            .|:.|:...||..|:.|||:||.|: ..:..:|:...|:|||.|||:........:.....:..|
Human   303 AWSEEECRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFAQQTRLGRRKYV 367

  Fly   244 KDGSENGSEVGSNEESDNDDKKGHG 268
            ..|:.:     ::::.|..|..|.|
Human   368 PSGTTD-----ADQDLDGSDPDGPG 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	18/53 (34%)
		SANT	179..225	CDD:197842	19/49 (39%)
		SANT	180..224	CDD:304392	17/44 (39%)
		SANT	540..582	CDD:238096
MIER2	NP_001374081.1	ELM2	199..249	CDD:396160	18/53 (34%)
MIER2	NP_001374081.1	SANT_MTA3_like	304..348	CDD:212559	17/43 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810