DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CoRest and rcor2

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_991201.1	Gene:	rcor2 / 402934	ZFINID:	ZDB-GENE-040426-1812	Length:	536	Species:	Danio rerio

Alignment Length:	624	Identity:	194/624 - (31%)
Similarity:	280/624 - (44%)	Gaps:	195/624 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 GAGTPESSDDDNSTKRNGKSKAKQSEYEE-----KIRVGRDYQAVCPPLVPEAERRPEQMNERAL 121
            |:|....|.....|..|.:...::|..||     .||||.||||..|...|:...|..:.::|::
Zfish     5 GSGVLSRSRAKTVTNGNSQHSEEESSDEEHPNDSMIRVGGDYQAQIPEFKPDCASRYGEKDQRSM 69

  Fly   122 LVWSPTKEIPDLKLEEYISVAKEKYGYNGEQALGMLFWHKHDLERAVMDLANFTPFPDEWTIEDK 186
            |||||..::.|..|:|||.:||||:|||.|||||||.|||||:|:::.|||||||||||||:|||
Zfish    70 LVWSPNSQVSDAMLDEYILMAKEKHGYNMEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDK 134

  Fly   187 VLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVVKDGSENGS 251
            |||||||.|||||||||:||||||.|.|||||||||||||.|:|.||||.:.:.          |
Zfish   135 VLFEQAFSFHGKSFHRIQQMLPDKMITSLVKYYYSWKKTRTRTSVMDRQARKLL----------S 189

  Fly   252 EVGSNEESDNDDKKGHGTNSTINTIDATTTSTNNSTTNSNTTTPANIIANTINSNHSSSNSGGGG 316
            :...||.:|..::...|::|...                            ||:...|:....|
Zfish   190 KREKNESNDEIEEGDPGSDSDFE----------------------------INAKKESAKQNSG- 225

  Fly   317 NINNNGEENIQAVGGSNTISNTSNNDMDAEQLSLFAGNAQIEEMMALGLAADRAIGANGGNNNNN 381
                                                                     |||.|
Zfish   226 ---------------------------------------------------------NGGGN--- 230

  Fly   382 GEMGGDPGLMRRMVVGGFCKICNVVCHVLHDSPLGRMCKSCHTHWRRTGNRRPISGPEGNAPRRS 446
             |.|..                                |||.|.             :.|...:.
Zfish   231 -EKGPS--------------------------------KSCLTR-------------KENQSAQY 249

  Fly   447 THNCAATADRSKRKPPKGMYINHDDLTAL-ASCGNPSLYLAERERKLTALMAEIQKNRQVMEQLD 510
            .|:..    |::|:|||||::..:|:.|| ||..:.::.:.:.:.:|.:|..::||.:|
Zfish   250 RHHPL----RARRRPPKGMHLEQEDIVALSASTDSGAVTIRQLDTQLVSLKRQVQKIKQ------ 304

  Fly   511 KECETINVDDVLSKPAAANTESAQPR-----ISARWLPDEIQVALLAIREYGKNFPTIAKVVATK 570
                   .:.||........|..:||     |::||..:|..:|:.|:|.|||:|..||.|:..|
Zfish   305 -------TNSVLRNNLGDGIEDMRPREPNQKINSRWTTEEQLLAVQAVRRYGKDFAAIADVIGNK 362

  Fly   571 TEAHVRTFYLNNRRRYNLDQIVKEYEAGKSEESGAEEQTEPAVDAAAAGAATAS---------AP 626
            |.|.|.:|:::.|||:||:::::|::| :.|..|:..:|   |:....|:|...         :|
Zfish   363 TVAQVSSFFVSYRRRFNLEEVLREWQA-EQEVQGSSGRT---VNTELNGSAELEDDEVKMDGISP 423

  Fly   627 SAADSTSAASATADRKQSTENSNNGVETMQESLPKKEDP 665
            ..:||.         ..|:|.|.:|..:..:|.|....|
Zfish   424 PHSDSP---------LPSSEGSASGNHSSAQSSPPLTQP 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	23/51 (45%)
		SANT	179..225	CDD:197842	40/45 (89%)
		SANT	180..224	CDD:304392	38/43 (88%)
		SANT	540..582	CDD:238096	18/41 (44%)
rcor2	NP_991201.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		11/38 (29%)
		ELM2	40..92	CDD:279754	23/51 (45%)
		SANT	127..173	CDD:197842	40/45 (89%)
		SANT	128..172	CDD:304392	38/43 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..264		31/233 (13%)
		SANT	332..377	CDD:197842	19/44 (43%)
		Myb_DNA-binding	332..375	CDD:278669	18/42 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..536		17/78 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596875
Domainoid	1	1.000	54	1.000	Domainoid score	I11254
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2733
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287298at33208
OrthoFinder	1	1.000	-	-		FOG0001182
OrthoInspector	1	1.000	-	-		otm25130
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3377
SonicParanoid	1	1.000	-	-		X1336
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.890