DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CoRest and Trerf1

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_038939419.1	Gene:	Trerf1 / 316219	RGDID:	1307167	Length:	1241	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	112/525 - (21%)
Similarity:	180/525 - (34%)	Gaps:	159/525 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GSG--NN---SGHSGNANANEKTTTAVPGAGTP-------ESSDDDNSTKRNGKSKAKQSEYEEK 91
            |||  :|   |||....:.....|...|   ||       .|.|..|.|...|..: :..:.|.:
  Rat   752 GSGLFSNVLISGHGPGVHPQLPLTPLTP---TPRVLLCRSSSIDGSNVTVTPGPGE-QTVDVEPR 812

  Fly    92 IRVGRDYQAVCPPLVPEAERRPEQMNERALLVWSPTKEIPDLKLEEYI--------SVAKEKYGY 148
            |.:|..:||..|.|  :......|...:|.|||.|..|:.:..|::.:        |.|....|.
  Rat   813 INIGLRFQAEIPEL--QDVSAMAQDTHKATLVWKPWPELENQALQQQVENLLNLCCSSALPGGGT 875

  Fly   149 NGEQALGMLFWHKHD----LERAVM---------DLANF-TPFPDEWTIEDKVLFEQAFQFHGKS 199
            |.|.||..||..|.|    ||..::         .|||: ....|:||..::.||.:|...:.|.
  Rat   876 NSEFALHSLFEAKGDVMATLETLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKD 940

  Fly   200 FHRIRQMLPDKSIASLVKYYYSWKK-----TRHRSSAMDRQEKAIKAVVKD--GSENGSEVGSNE 257
            |..:::|:..|::|..|:|||:|||     .:||:        .:..::.|  .||...:....|
  Rat   941 FIFVQKMVKSKTVAQCVEYYYTWKKIMRLGRKHRT--------RLAEIIDDCMTSEEEEDAEEEE 997

  Fly   258 ESDNDDKKGHGTNSTINTIDATTTSTNNSTTNSNTTTPANIIANTINSNHSSSNSGGGGNINN-- 320
            |...:|:|             :.....:....:....||..:|.|..:...:.....|..|..
  Rat   998 EDPEEDRK-------------SIKDEESEVPKTPEPPPAPALAPTEGAPMQAGGQPSGSFICEMP 1049

  Fly   321 ------------------------NGEENIQAVGGSNTISNTSNNDMDAEQLSLFAGNAQIEEMM 361
                                    ||...|.  ||:|.::.|.......:|.   .|..|
  Rat  1050 NCGADCRCHVAPFLPQVFSSRQALNGHARIH--GGTNQVAKTRGAVPSGKQK---PGGTQ----- 1104

  Fly   362 ALGLAADRAIGANGGNNNNNGEMGGDPGLMRRMVVGGF-CKICNVVCHVLHDSPLGRMCKSCH-- 423
                :...::.::..::..:||.  ||..:       | ||.|..|...:..       ::.|
  Rat  1105 ----SGYCSVKSSPSHSTTSGET--DPTTI-------FPCKECGKVFFKIKS-------RNAHMK 1149

  Fly   424 THWRRTGNRR---------------------PISGPEGNAPRRSTHNCAATADRSKRKPPKGMYI 467
            ||.::...:|                     |:..||           ....|:.....||.:.|
  Rat  1150 THRQQEEQQRQKAQKAAFAAEMAATIERTTGPVGAPE-----------LLPLDQLSLMKPKDVDI 1203

  Fly   468 NHDDL 472
            ..||:
  Rat  1204 LDDDM 1208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	16/59 (27%)
		SANT	179..225	CDD:197842	18/50 (36%)
		SANT	180..224	CDD:304392	15/43 (35%)
		SANT	540..582	CDD:238096
Trerf1	XP_038939419.1	PRK10263	<219..>390	CDD:236669
		zf-C2H2_6	520..540	CDD:404748
		ELM2	813..867	CDD:396160	14/55 (25%)
		SANT	921..965	CDD:419695	15/43 (35%)
		zf-C2H2_6	1128..1151	CDD:404748	6/36 (17%)
		C2H2 Zn finger	1129..1151	CDD:275369	6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810