DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CoRest and Mier1

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_017448862.1	Gene:	Mier1 / 313418	RGDID:	1562337	Length:	698	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	95/422 - (22%)
Similarity:	149/422 - (35%)	Gaps:	106/422 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 NNSGHSGNANANEKTTTAVPGAGTPESSDDDNSTK------------RNGKSKAKQSEYEE---- 90
            :|||.||. |..|....:.......:||:||.|..            |..|.....||.||
  Rat   291 DNSGCSGE-NKEENIKDSSGQEDETQSSNDDPSQSVTSQDAQEIIRPRRCKYFDTNSEIEEESEE 354

  Fly    91 ------------KIRVGRDYQAVCPPLVPEAERRPEQMNERALLVWSPTKEIPDLKLEEYISVAK 143
                        :|.||..:||..|..|...:...:.......|:|.| :.:|:.|:..::..|.
  Rat   355 DEDYIPSEDWKKEIMVGSMFQAEIPVGVCRYKENEKVYENDDQLLWDP-EYLPEDKVIVFLKDAS 418

  Fly   144 EKYG--------------YNGEQALGMLFWHKHDLERAVMDLA-NFTPFPDE---WTIEDKVLFE 190
            .:.|              .:.||||..|.....|.|.|:..|. |.....:|   ||.|:...||
  Rat   419 RRTGDEKGVEAIPEGSHIKDNEQALYELVKCSFDTEEALRRLRFNVKAAREELSVWTEEECRNFE 483

  Fly   191 QAFQFHGKSFHRIR-QMLPDKSIASLVKYYYSWKKTRH-----RSSAMDRQEKAIKAVVKDG--- 246
            |..:.:||.||.|: ..:..:|:...|.:||.|||:..     :.:...:::..:...|.|.
  Rat   484 QGLKAYGKDFHLIQANKVRTRSVGECVAFYYMWKKSERYDFFAQQTRFGKKKYNLHPGVTDYMDR 548

  Fly   247 --SENGSEVGSNEESDNDDKKGHGTNSTINTIDATTTSTNNSTTNSNTTTPANIIANTINSNHSS 309
              .|:.|...|...|                  ...|::|:||:.|....     ....|||.:.
  Rat   549 LLDESESAASSRAPS------------------PPPTASNSSTSQSEKED-----GTLSNSNQNG 590

  Fly   310 SNSGGGGNINNNGEENIQAV------GGSN--TISNTSNNDMDAEQLSLFAGNAQIEEMMALGLA 366
            .:|.|.|.|.|..|..::.:      ||:.  .:::...|..:...|   |.:.::..|.|
  Rat   591 VSSNGPGEILNKEEVKVEGLHVNGPTGGNKKPLLTDVDTNGYEENNL---ATDPKLAHMTA---- 648

  Fly   367 ADRAIGANGGNNNNNGEMGGDPGLMRRMVVGG 398
                     .|.|:..|....|...||:...|
  Rat   649 ---------RNENDFDEKNERPAKRRRINSSG 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	13/51 (25%)
		SANT	179..225	CDD:197842	18/49 (37%)
		SANT	180..224	CDD:304392	17/47 (36%)
		SANT	540..582	CDD:238096
Mier1	XP_017448862.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810