DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CoRest and Mier3

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_006231987.2	Gene:	Mier3 / 310086	RGDID:	1311241	Length:	704	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	100/496 - (20%)
Similarity:	181/496 - (36%)	Gaps:	123/496 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NTTDVVRNGRRSRGPSPNTHTTGGVTNSASLVGSGNNSGHSGNANANEKTTTAVPGAGTPESSDD 71
            :|...|.|...:..||........:|.....:.....||......::....|  |...:.|:||.
  Rat   233 STIPTVANSSANSSPSELADELPDMTLDKEEIAKDLLSGDDEETQSSADDLT--PSVTSHETSDF 295

  Fly    72 -----DNSTKRNGKSKAKQSEYEE--------------KIRVGRDYQAVCPPLVPEAERRPEQMN 117
                 .::|..:|.   |:||.|:              :|.:|..|||..||.:.|.....:...
  Rat   296 FPRPLRSNTTCDGD---KESEIEDVETDSGNSPEDLRKEIMIGLQYQAEIPPYLGEYSGDEKAYE 357

  Fly   118 ERALLVWSPTKEIPDLKLEEYISVAKEKYGYNGEQALGMLF--WHKHDLERAVMDLA----NFTP 176
            ....|:|.| ..:.:.|::||:.....:.|  .|:.|..:.  .|..|.|:|:.:|.    |.|.
  Rat   358 NEDQLLWRP-DVVLESKVKEYLIETSLRTG--NEKVLDRISSGTHTRDNEQALYELLKCNHNVTE 419

  Fly   177 FPDE--------------WTIEDKVLFEQAFQFHGKSFHRI-RQMLPDKSIASLVKYYYSWKKT- 225
            ..:.              ||.|:...||.|...:||.||.| :..:..:::|..|.:||.|||:
  Rat   420 AIERYCCNGKASQEGMTAWTEEECRSFEHALMLYGKDFHLIQKNKVRSRTVAECVAFYYMWKKSE 484

  Fly   226 ----------------RHRSSAMDRQEKAIKAVVKDGSEN-GSEVGSNEESDNDDKKGHGTNSTI 273
                            .|.....|..::.:     |.:|: |..|.|:..:.|  :.....:..:
  Rat   485 RYDYFAQQTKFGKKRYNHHPGVTDYMDRLV-----DETESLGDTVSSSALTSN--RPEPIPDQPL 542

  Fly   274 NTIDATTTSTNNSTTNSNTT--TPANIIANTINSNHSSSNSGGGGNIN-------------NNGE 323
            |.:.:.|.|...:.|||..|  .|.::  :.::.:.|...:...|.:|             :|||
  Rat   543 NILSSFTASDLTALTNSVATVCNPTDV--SCLDDSFSPLGNAPRGQVNHVPVVTEELLTLPSNGE 605

  Fly   324 E---NIQAVGGSNTISNTSNNDMDAEQLSLFAGNAQIEEMMALGLAADRA---------IGANGG 376
            .   |:...|    ..::..|.|.:|:      :.:..:.:.:|:|...:         :|.:..
  Rat   606 SDCFNLFETG----FYHSELNPMCSEE------SERPAKRLKMGIAVPESFMNEVSVNNLGVDFE 660

  Fly   377 NNNN---NGEMG---GDPGLMRRMVVGGFCKICNVVCHVLH 411
            |:.:   :.:|.   .|.|.:......||     :..|.||
  Rat   661 NHTHHITSAKMAVSVADFGSLSASETNGF-----INAHTLH 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	14/51 (27%)
		SANT	179..225	CDD:197842	17/60 (28%)
		SANT	180..224	CDD:304392	16/58 (28%)
		SANT	540..582	CDD:238096
Mier3	XP_006231987.2	ELM2	332..380	CDD:279754	14/48 (29%)
		SANT	436..483	CDD:197842	17/46 (37%)
		SANT_MTA3_like	438..482	CDD:212559	16/43 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810