DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CoRest and RCOR1

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_055971.2	Gene:	RCOR1 / 23186	HGNCID:	17441	Length:	485	Species:	Homo sapiens

Alignment Length:	645	Identity:	185/645 - (28%)
Similarity:	289/645 - (44%)	Gaps:	210/645 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RNGRRSRGPSPNTHTTGGVTNS--ASLVGSGNNSGHSGNANANEKTTTAVPGAGTPES----SDD 71
            |.||.:...|.:........::  ||...:..:...:.:|:|...:..|.|..|..:|    :.:
Human    15 RRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPN 79

  Fly    72 DNSTKRNGKSKAKQSEYEEK-----IRVGRDYQAVCPPLVP-EAERRPEQMNERALLVWSPTKEI 130
            .||:..:.:..:..|..:|:     :|||..||||.|...| :..||.::.:...:|||||.:.:
Human    80 GNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNL 144

  Fly   131 PDLKLEEYISVAKEKYGYNGEQALGMLFWHKHDLERAVMDLANFTPFPDEWTIEDKVLFEQAFQF 195
            .:.||:|||::||||:|||.||||||||||||::|:::.||.||||||||||:||||||||||.|
Human   145 SEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSF 209

  Fly   196 HGKSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVVKDGSENGSEVGSNEESD 260
            |||:||||:|||||||||||||:||||||||.::|.|||..:..|.             ..|||:
Human   210 HGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKR-------------EREESE 261

  Fly   261 NDDKKGHGTNSTINTIDATTTSTNNSTTNSNTTTPANIIANTINSNHSSSNSGGGGNINNNGEEN 325
            ::.::.:|.|                        |.:|                  .::.| :|:
Human   262 DELEEANGNN------------------------PIDI------------------EVDQN-KES 283

  Fly   326 IQAVGGSNTISNTSNNDMDAEQLSLFAGNAQIEEMMALGLAADRAIGANGGNNNNNGEMGGDPGL 390
            .:.|..:.|:
Human   284 KKEVPPTETV------------------------------------------------------- 293

  Fly   391 MRRMVVGGFCKICNVVCHVLHDSPLGRMCKSCHTHWRRTGNRRPISGPEGNAPRRSTHNCAATAD 455
                                                           |:....:.||.    ..:
Human   294 -----------------------------------------------PQVKKEKHSTQ----AKN 307

  Fly   456 RSKRKPPKGMYINHDDLTAL-ASCGNPSLYLAERERKLTALMAEIQK----NRQVMEQLDKECET 515
            |:||||||||:::.:|:.|: |:....:..|.:.:.:|.::..:||.    |..:.|:||...|.
Human   308 RAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEP 372

  Fly   516 INVDDVLSKPAAANTESAQPRISARWLPDEIQVALLAIREYGKNFPTIAKVVATKTEAHVRTFYL 580
            ..:.:|:.|            .:|||..:|..:|:.|||:||::|..|:.|:..|:...|:.|::
Human   373 YRLPEVIQK------------CNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFV 425

  Fly   581 NNRRRYNLDQIVKEYEA--GKSEESG-----------------AEEQTEPAVDAAAAGAA 621
            |.|||:|:|::::|:||  ||.|.:|                 .||...|.:|...|.|:
Human   426 NYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	22/52 (42%)
		SANT	179..225	CDD:197842	40/45 (89%)
		SANT	180..224	CDD:304392	38/43 (88%)
		SANT	540..582	CDD:238096	15/41 (37%)
RCOR1	NP_055971.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		4/10 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..110		13/60 (22%)
		Interaction with HDAC1. /evidence=ECO:0000269\|PubMed:11516394	78..257		101/191 (53%)
		ELM2	105..158	CDD:307553	22/52 (42%)
		SANT	194..238	CDD:328756	38/43 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..314		23/231 (10%)
		Interaction with KDM1A. /evidence=ECO:0000269\|PubMed:16885027	296..384		25/103 (24%)
		Myb_DNA-binding	385..428	CDD:306708	16/42 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..485		10/42 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11581
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32246
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2733
Isobase	1	0.950	-	0	Normalized mean entropy	S5681
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287298at33208
OrthoFinder	1	1.000	-	-		FOG0001182
OrthoInspector	1	1.000	-	-		otm41292
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3377
SonicParanoid	1	1.000	-	-		X1336
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.950