Protein Alignment CoRest and Rcor1

DIOPT Version :10

• Sequence 1: NP_001188671.1
• Gene: CoRest / 32941
• FlyBaseID: FBgn0261573
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_932140.2
• Gene: Rcor1 / 217864
• MGIID: 106340
• Length: 480
• Species: Mus musculus
• Alignment Length: 688
• Identity: 193/688 - (28%)
• Similarity: 298/688 - (43%)
• Gaps: 237/688 - (34%)

  Fly    14 NGRRSRGPSPNTHTTGGVTNSASLVGSGNNSGHSGNANANEKTTTAVP---------GAGTPESS 69
            :|:| ||.:..........::||...|...|..:.:|:|....:.|..         .|..|..:
Mouse    12 SGKR-RGRNTAASAASAAASAASAAASAAASAGTASASAAAAASAAAAPNNGQNKSLAAAAPNGN 75

  Fly    70 DDDNSTKRNGKSKAKQSEY-EEKIRVGRDYQAVCPPLVP-EAERRPEQMNERALLVWSPTKEIPD 132
            ...||.:......:...|: ...:|||..|||..|...| :..||.::.:...:|||||.:.:.:
Mouse    76 SGSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAAVPDFDPAKLARRSQERDNLGMLVWSPNQSLSE 140

  Fly   133 LKLEEYISVAKEKYGYNGEQALGMLFWHKHDLERAVMDLANFTPFPDEWTIEDKVLFEQAFQFHG 197
            .||:|||::||||:|||.||||||||||||::|:::.||.||||||||||:||||||||||.|||
Mouse   141 AKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHG 205

  Fly   198 KSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVVKDGSENGSEVGSNEESDND 262
            |:||||:|||||||||||||:||||||||.::|.|||..:..|.             ..|||:::
Mouse   206 KTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKR-------------EREESEDE 257

  Fly   263 DKKGHGTNSTINTIDATTTSTNNSTTNSNTTTPANIIANTINSNHSSSNSGGGGNINNNGEENIQ 327
            .::.:|:|                        |.:|                  .|:.| :|:.:
Mouse   258 LEETNGSN------------------------PVDI------------------EIDPN-KESKK 279

  Fly   328 AVGGSNTISNTSNNDMDAEQLSLFAGNAQIEEMMALGLAADRAIGANGGNNNNNGEMGGDPGLMR 392
            .|..:.|:
Mouse   280 EVPPTETV--------------------------------------------------------- 287

  Fly   393 RMVVGGFCKICNVVCHVLHDSPLGRMCKSCHTHWRRTGNRRPISGPEGNAPRRSTHNCAATADRS 457
                                                         |:....:.||.    ..:|:
Mouse   288 ---------------------------------------------PQVKKEKHSTQ----AKNRA 303

  Fly   458 KRKPPKGMYINHDDLTAL-ASCGNPSLYLAERERKLTALMAEIQK----NRQVMEQLDKECETIN 517
            ||||||||:::.:|:.|: |:....:..|.:.:.:|.::..:||.    |..:.|:||...|...
Mouse   304 KRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSIKRQIQNIKQTNSALKEKLDGGIEPYR 368

  Fly   518 VDDVLSKPAAANTESAQPRISARWLPDEIQVALLAIREYGKNFPTIAKVVATKTEAHVRTFYLNN 582
            :.:|:.|            .:|||..:|..:|:.|||:||::|..|:.|:..|:...|:.|::|.
Mouse   369 LPEVIQK------------CNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNY 421

  Fly   583 RRRYNLDQIVKEYEA--GKSEESGAEEQTEPAVDAAAAGAATASAPSAADSTSAASATADRKQST 645
            |||:|:|::::|:||  ||.|.:|...| :|.                              :|.
Mouse   422 RRRFNIDEVLQEWEAEHGKDETNGPANQ-KPV------------------------------KSP 455

  Fly   646 ENSNNGVETMQESLPKKEDPKKPELAAAVLKIGVAEAA 683
            |:|        ..:|::||.     ||:||.:..|.|:
Mouse   456 ESS--------IKIPEEEDE-----AASVLDVRYASAS 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:460214	21/52 (40%)
		SANT	180..224	CDD:473887	38/43 (88%)
		Myb_DNA-binding	540..583	CDD:459731	16/42 (38%)
Rcor1	NP_932140.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		19/93 (20%)
		Interaction with HDAC1. /evidence=ECO:0000250|UniProtKB:Q9UKL0	72..251		100/191 (52%)
		ELM2	99..152	CDD:460214	21/52 (40%)
		SANT	188..232	CDD:473887	38/43 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..308		24/231 (10%)
		Interaction with KDM1A. /evidence=ECO:0000250|UniProtKB:Q9UKL0	290..378		25/103 (24%)
		Myb_DNA-binding	379..422	CDD:459731	16/42 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	436..466		11/68 (16%)