DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CoRest and Rcor3

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_030108730.2	Gene:	Rcor3 / 214742	MGIID:	2441920	Length:	633	Species:	Mus musculus

Alignment Length:	753	Identity:	211/753 - (28%)
Similarity:	312/753 - (41%)	Gaps:	262/753 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GRRSRGP---SPNTHTTGGVTNSASLVGSGNNSG------HSGNANANEKTTTAV-----PGAGT 65
            |...:||   ..:....||..:.|...||..|.|      .||.::.:|...|:.     |.|..
Mouse     3 GMMEKGPELLGKSRSANGGAKSPAGGGGSSANGGLHFSEPESGCSSDDEHGGTSPRSPPRPSARP 67

  Fly    66 PESS---DDDNSTKRNGKSKAK-----------------------------QSEY---------- 88
            |..:   .:.:..:||.:.:..                             .|.|
Mouse    68 PPRALLPSEPSRGRRNSRCRRSPRPAPPRPHPATASPALPRLESLCLALPLSSPYLLPFYHISWH 132

  Fly    89 ---EEKIRVGRDYQAVCPPLVPEAERRPEQMNERALLVWSPTKEIPDLKLEEYISVAKEKYGYNG 150
               :..:|||.:|||..|...|.|.:..::.| ..:|||||...|||.||:|||::||||:|||.
Mouse   133 CFADVGMRVGAEYQARIPEFDPGATKYTDKDN-GGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNV 196

  Fly   151 EQALGMLFWHKHDLERAVMDLANFTPFPDEWTIEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASL 215
            ||||||||||||::|:::.||.||||||||||:||||||||||.|||||||||:||||||:||||
Mouse   197 EQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASL 261

  Fly   216 VKYYYSWKKTRHRSSAMDRQEKAIKAVVKDGSENGSEVGSNEESDNDDKKGHGTNSTINTIDATT 280
            |||||||||||.|:|.||||.:.:......|           :||:|.::.|..:
Mouse   262 VKYYYSWKKTRSRTSLMDRQARKLANRHNQG-----------DSDDDVEEAHPMD---------- 305

  Fly   281 TSTNNSTTNSNTTTPANIIANTINSNHSSSNSGGGGNINNNGEENIQAVGGSNTISNTSNNDMDA 345
                                               ||                      ::|.|.
Mouse   306 -----------------------------------GN----------------------DSDYDP 313

  Fly   346 EQLSLFAGNAQIEEMMALGLAADRAIGANGGNNNNNGEMGGDPGLMRRMVVGGFCKICNVVCHVL 410
            ::.:...||            ||:.:        ...::|
Mouse   314 KKEAKREGN------------ADQPV--------QTSKIG------------------------- 333

  Fly   411 HDSPLGRMCKSCHTHWRRTGNRRPISGPEGNAPRRSTHNCAATADRSKRKPPKGMYINHDDLTAL 475
                |||.                    |..:.:...|     :.|||.:||||||:..:|:.|:
Mouse   334 ----LGRR--------------------EYQSLQHRHH-----SQRSKCRPPKGMYLTQEDVVAV 369

  Fly   476 ASCGN-PSLYLAERERKLTALMAEIQKNRQVMEQLDKECETINVDDVLSKPAAANTESAQPRISA 539
            :...| .:..|.:.:.:|.:|..::|..:||...|.::.|. .:::.  ||..:|     .:|:|
Mouse   370 SCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEG-GIEEF--KPPESN-----QKINA 426

  Fly   540 RWLPDEIQVALLAIREYGKNFPTIAKVVATKTEAHVRTFYLNNRRRYNLDQIVKEYEAGKSEESG 604
            ||..:|..:|:..:|:|||:|..||.|:..||...|:.|::|.|||:||:::::|:||    |.|
Mouse   427 RWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEVLQEWEA----EQG 487

  Fly   605 AEEQTEPAVDAAAAGAATASAPSAADSTSAASATADRKQSTENSNNGVETMQESLPKKEDPKKPE 669
            .:             |:.|.|.:..:.|.:||.....|.:.|.:    |......|:...|..|
Mouse   488 TQ-------------ASNADASALGEETQSASKVPSGKSTDEEA----EAQTPQAPRTLGPSPP- 534

  Fly   670 LAAAVLKIGVAEAADAVATVASSTASGVIGAATSASKP 707
                               ..|||.:..:..||....|
Mouse   535 -------------------APSSTPTPTVPIATLNQPP 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	24/51 (47%)
		SANT	179..225	CDD:197842	41/45 (91%)
		SANT	180..224	CDD:304392	39/43 (91%)
		SANT	540..582	CDD:238096	16/41 (39%)
Rcor3	XP_030108730.2	ELM2	139..190	CDD:396160	24/51 (47%)
		SANT	226..270	CDD:419695	39/43 (91%)
		Myb_DNA-binding	427..470	CDD:395191	17/42 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850839
Domainoid	1	1.000	51	1.000	Domainoid score	I11486
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2681
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287298at33208
OrthoFinder	1	1.000	-	-		FOG0001182
OrthoInspector	1	1.000	-	-		otm43348
orthoMCL	1	0.900	-	-		OOG6_108075
Panther	1	1.100	-	-	LDO	PTHR16089
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1336
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760