DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CoRest and MIER3

DIOPT Version :9

Sequence 1:	NP_001188671.1	Gene:	CoRest / 32941	FlyBaseID:	FBgn0261573	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_011541518.1	Gene:	MIER3 / 166968	HGNCID:	26678	Length:	566	Species:	Homo sapiens

Alignment Length:	505	Identity:	101/505 - (20%)
Similarity:	174/505 - (34%)	Gaps:	141/505 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TTDVVRNGRRSRGPSPNTHTTGGVTNSASLVGSGNNSGHSGNANANEKTTTAVPGAGTPESSDD- 71
            |...|.|...:..||........:|.....:.....||......::....|  |...:.|:||.
Human    94 TIPAVANSSANSSPSELADELPDMTLDKEEIAKDLLSGDDEETQSSADDLT--PSVTSHETSDFF 156

  Fly    72 ----DNSTKRNGKSKAKQSEYEE--------------KIRVGRDYQAVCPPLVPEAERRPEQMNE 118
                .::|..:|.   |:||.|:              :|.:|..|||..||.:.|.:...:....
Human   157 PRPLRSNTACDGD---KESEVEDVETDSGNSPEDLRKEIMIGLQYQAEIPPYLGEYDGNEKVYEN 218

  Fly   119 RALLVWSPTKEIPDLKLEEY-----ISVAKEK---------YGYNGEQALGMLFWHKHDLERAVM 169
            ...|:|.| ..:.:.|::||     :....||         :..:.||||..|....|:::.|:.
Human   219 EDQLLWCP-DVVLESKVKEYLVETSLRTGSEKIMDRISAGTHTRDNEQALYELLKCNHNIKEAIE 282

  Fly   170 DLANFTPFPDE----WTIEDKVLFEQAFQFHGKSFHRI-RQMLPDKSIASLVKYYYSWKKT---- 225
            ..........|    ||.|:...||.|....||.||.| :..:..:::|..|.:||.|||:
Human   283 RYCCNGKASQEGMTAWTEEECRSFEHALMLFGKDFHLIQKNKVRTRTVAECVAFYYMWKKSERYD 347

  Fly   226 -------------RHRSSAMDRQEKAI-KAVVKDGSENGSEVGSNEESDNDDKKGHGTNSTINTI 276
                         .|.....|..::.: :.....|:.|.|.:.||......|::       :|.:
Human   348 YFAQQTRFGKKRYNHHPGVTDYMDRLVDETEALGGTVNASALTSNRPEPIPDQQ-------LNIL 405

  Fly   277 DATTTSTNNSTTNSNTTT--PANIIANTINSNHSSSNSGGGGNIN-------------NNGEE-- 324
            ::.|.|...:.|||..|.  |.::  |.::.:.....:...|.:|             :|||.
Human   406 NSFTASDLTALTNSVATVCDPTDV--NCLDDSFPPLGNTPRGQVNHVPVVTEELLTLPSNGESDC 468

  Fly   325 -NIQAVGGSNTISNTSN-----NDMDAEQLSL-------FAGNAQIEEM---------------M 361
             |:...|..::..|..|     ::..|::|.:       |.....:..:               |
Human   469 FNLFETGFYHSELNPMNMCSEESERPAKRLKMGIAVPESFMNEVSVNNLGVDFENHTHHITSAKM 533

  Fly   362 ALGLAADRAIGANGGNNNNNGEMGGDPGLMRRMVVGGFCKICNVVCHVLH 411
            |:.:|...::.||..|                    ||     :..|.||
Human   534 AVSVADFGSLSANETN--------------------GF-----ISAHALH 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CoRest	NP_001188671.1	ELM2	92..144	CDD:279754	14/56 (25%)
		SANT	179..225	CDD:197842	18/50 (36%)
		SANT	180..224	CDD:304392	17/48 (35%)
		SANT	540..582	CDD:238096
MIER3	XP_011541518.1	ELM2	192..240	CDD:396160	14/48 (29%)
MIER3	XP_011541518.1	SANT_MTA3_like	298..342	CDD:212559	16/43 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810