DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh3a and Idh3b

DIOPT Version :9

Sequence 1:	NP_001259705.1	Gene:	Idh3a / 32940	FlyBaseID:	FBgn0027291	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_446033.1	Gene:	Idh3b / 94173	RGDID:	621881	Length:	385	Species:	Rattus norvegicus

Alignment Length:	375	Identity:	155/375 - (41%)
Similarity:	240/375 - (64%)	Gaps:	20/375 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LIAARDAPAVTA--TPAVSQVNATPAASRSYS-----SGTKKVTLIPGDGIGPEISAAVQKIFTA 72
            ::.||::.|...  |.|.:|     |||:|.:     .|...||::||||:|||:..||:::|.|
  Rat    14 VLGARNSGAWRGLRTAASAQ-----AASQSQAQDVRVEGAFPVTMLPGDGVGPELMHAVKEVFKA 73

  Fly    73 ANVPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVG-KGH-RSLNLALRKEFN 135
            |.||:|::...::.|:....:..:.| .:.|:..||:.:.|.:.||:. ||. .|.::.||::.:
  Rat    74 AAVPVEFKEHHLSEVQNMASEEKLEQ-VLSSMKENKVAIIGKIYTPMEYKGELASYDMQLRRKLD 137

  Fly   136 LYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAF 200
            |:|||...:||.||||.::::|:|.|||.||||||.:|||...||::.:|::|...|:|:|::||
  Rat   138 LFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRTKSQRIAKFAF 202

  Fly   201 QYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVL 265
            .||....|.|||.|||||||::.|||||:|..::|:.:|:|:||...:|..|:.:||||.::|||
  Rat   203 DYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVL 267

  Fly   266 VMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIA---GKDLANPTALLLSAV 327
            |||||||:|:.::.||||||.|:.|..:.....|:||:  |.....|   |:::|||||:||||.
  Rat   268 VMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFET--GARHPFAQAVGRNIANPTAMLLSAS 330

  Fly   328 MMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 377
            .||||:.|..::..|..|..:.||.||..|.|:||.:..::|...:...|
  Rat   331 NMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3a	NP_001259705.1	Iso_dh	46..377	CDD:294303	144/335 (43%)
Idh3b	NP_446033.1	Iso_dh	47..380	CDD:294303	144/335 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53770
OrthoDB	1	1.010	-	-		D325037at33208
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830