DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Idh3a and IDH-V

DIOPT Version :9

Sequence 1:	NP_001259705.1	Gene:	Idh3a / 32940	FlyBaseID:	FBgn0027291	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_568113.1	Gene:	IDH-V / 831884	AraportID:	AT5G03290	Length:	374	Species:	Arabidopsis thaliana

Alignment Length:	384	Identity:	219/384 - (57%)
Similarity:	283/384 - (73%)	Gaps:	19/384 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAARFIQKILNQLGLIAARDAPAVTATPAVSQVNATPAA----SRSYSSGTKKV--TLIPGDGIG 59
            |||...::::..            .:|..:..||::..|    :|::.|.|..:  ||.||||||
plant     3 MAANLARRLIGN------------RSTQILGAVNSSSGAASSVARAFCSSTTPITATLFPGDGIG 55

  Fly    60 PEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHR 124
            |||:.:|:|:||.|.||||||...|.....|..:..:...:::||..||:|||||:.||:|||||
plant    56 PEIAESVKKVFTTAGVPIEWEEHYVGTEIDPRTQSFLTWESLESVRRNKVGLKGPMATPIGKGHR 120

  Fly   125 SLNLALRKEFNLYANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITE 189
            ||||.||||.|||||||||.||.||||.|||||::||||||||||||:||::|.|||:|:|:||.
plant   121 SLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVRGVVESLKIITR 185

  Fly   190 EASKRVAEYAFQYAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLN 254
            :||.|||||||.|||.:.|::|:.:||||||:.:|||||:|.|::|:|:|||.:||..:|..|:.
plant   186 QASLRVAEYAFLYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEKYPEITYEEVVIDNCCMM 250

  Fly   255 MVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLAN 318
            :|:||..:||||||||||||:||:|||||||||||||.|:|.:| ||.|:|||:|||||||:|||
plant   251 LVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSCNIGEDGVALAEAVHGSAPDIAGKNLAN 315

  Fly   319 PTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 377
            |||||||.||||||::.|..|::|..|...||.||||.|.||||.:..:|||..||..|
plant   316 PTALLLSGVMMLRHLKFNEQAEQIHSAIINTIAEGKYRTADLGGSSTTTEFTKAICDHL 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Idh3a	NP_001259705.1	Iso_dh	46..377	CDD:294303	209/333 (63%)
IDH-V	NP_568113.1	PLN00118	3..374	CDD:215062	218/382 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	426	1.000	Domainoid score	I113
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4037
Inparanoid	1	1.050	434	1.000	Inparanoid score	I415
OMA	1	1.010	-	-		QHG53770
OrthoDB	1	1.010	-	-		D868374at2759
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	1	1.000	-	-		mtm1151
orthoMCL	1	0.900	-	-		OOG6_100541
Panther	1	1.100	-	-	LDO	PTHR11835
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X402
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840