Protein Alignment Idh3a and IDH3G

DIOPT Version :10

• Sequence 1: NP_001259705.1
• Gene: Idh3a / 32940
• FlyBaseID: FBgn0027291
• Length: 377
• Species: Drosophila melanogaster
• Sequence 2: NP_004126.1
• Gene: IDH3G / 3421
• HGNCID: 5386
• Length: 393
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 155/368 - (42%)
• Similarity: 229/368 - (62%)
• Gaps: 25/368 - (6%)

  Fly    15 LIAARDAPAVTATPAVSQVNATPAASRSYSSGTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEW 79
            ::.|.:.|   :....|:....|:|.   ..|...||:|||||||||:...|:.:|..|.||:::
Human    28 VLGAHEVP---SRNIFSEQTIPPSAK---YGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDF 86

  Fly    80 EAVDVT------PVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMT--PVGKGHRSLNLALRKEFNL 136
            |.|.|:      .:|.          ||.::..|::.|||.:.|  .:...|:|.|..||...:|
Human    87 EEVHVSSNADEEDIRN----------AIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDL 141

  Fly   137 YANVRPCRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQ 201
            ||||..|:||.|..|.:.|:|::.:|||||||||.:|||.|.|||:|:|:||:..|.|:|||||:
Human   142 YANVIHCKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFK 206

  Fly   202 YAKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLV 266
            .|:.:.|||||.|||||||::.|||||:|.|::|.::|:|.||...:|...:.:|..|.::||:|
Human   207 LAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMV 271

  Fly   267 MPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFE-SVHGTAPDIAGKDLANPTALLLSAVMML 330
            ||||||:|::::|||||||.||....|.|...|:|| :...|...||.|::|||||.||::.|||
Human   272 MPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMML 336

  Fly   331 RHMELNTYADKIERAAFETIKEGKYLTGDLGGRAKCSEFTNEI 373
            .|::|::||..|.:|...::......|.|:||:...||...::
Human   337 DHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDV 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Idh3a	NP_001259705.1	Iso_dh	46..377	CDD:444908	150/337 (45%)
IDH3G	NP_004126.1	mito_nad_idh	52..383	CDD:272942	150/338 (44%)