Protein Alignment Idh3a and IDH3A

DIOPT Version :10

• Sequence 1: NP_001259705.1
• Gene: Idh3a / 32940
• FlyBaseID: FBgn0027291
• Length: 377
• Species: Drosophila melanogaster
• Sequence 2: NP_005521.1
• Gene: IDH3A / 3419
• HGNCID: 5384
• Length: 366
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 247/361 - (68%)
• Similarity: 295/361 - (81%)
• Gaps: 9/361 - (2%)

  Fly    26 ATPA-VSQVNATPAA-------SRSYSSGTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAV 82
            |.|| :|:|:....|       :|.::.|.:.|||||||||||||||||.|||.||..||:||..
Human     2 AGPAWISKVSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEER 66

  Fly    83 DVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLE 147
            :||.::||.||:.||..|.:|::.||:||||||.||:..||.|:||.|||.|:||||||||.|:|
Human    67 NVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIE 131

  Fly   148 GYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNRKKVT 212
            ||||.|.||::||||||||||||||||.||||||||||||||.||||:||:||:||:||:|..||
Human   132 GYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVT 196

  Fly   213 VVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSD 277
            .|||||||||||||||:..|::|:...:|:|.|.|||||||||||:|.::|||||||||||||||
Human   197 AVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSD 261

  Fly   278 MCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADK 341
            :||||:||||:|||||:|.|| |:|||||||||||||||:|||||||||||||||||.|..:|.:
Human   262 LCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAR 326

  Fly   342 IERAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 377
            ||.|.|.|||:||.||.||||.||||:||.|||.::
Human   327 IEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Idh3a	NP_001259705.1	Iso_dh	46..377	CDD:444908	240/331 (73%)
IDH3A	NP_005521.1	mito_nad_idh	29..362	CDD:272942	240/332 (72%)