Protein Alignment Idh3a and idh2

DIOPT Version :10

• Sequence 1: NP_001259705.1
• Gene: Idh3a / 32940
• FlyBaseID: FBgn0027291
• Length: 377
• Species: Drosophila melanogaster
• Sequence 2: NP_595203.2
• Gene: idh2 / 2541260
• PomBaseID: SPBC902.05C
• Length: 379
• Species: Schizosaccharomyces pombe
• Alignment Length: 361
• Identity: 209/361 - (57%)
• Similarity: 270/361 - (74%)
• Gaps: 9/361 - (2%)

  Fly    25 TATPAVSQVNATPAASRSY-----SSGTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDV 84
            :|..:..:.::|.||:.:|     ::|...||:|.||||||||:.:|::||.||.||||||.|.|
pombe    19 SACYSFQRFSSTKAAAGTYEGVKNANGNYTVTMIAGDGIGPEIAQSVERIFKAAKVPIEWERVKV 83

  Fly    85 TPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSLNLALRKEFNLYANVRPCRSLEGY 149
            .|:. .:|...||..|.:||..||:.|||||.||:||||.|:||.||:.|.|:||||||.|:.||
pombe    84 YPIL-KNGTTTIPDDAKESVRKNKVALKGPLATPIGKGHVSMNLTLRRTFGLFANVRPCVSITGY 147

  Fly   150 KTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNRKKVTVV 214
            ||.||:|:.|.|||||||||||||||::.||||||||||..||:||..||||||:...:..:|||
pombe   148 KTPYDNVNTVLIRENTEGEYSGIEHEVIPGVVQSIKLITRAASERVIRYAFQYARQTGKNNITVV 212

  Fly   215 HKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYD--VLVMPNLYGDILSD 277
            |||.||||:|||||.|.:::|.::|:|:..|:.||..||.:|.:|..|:  |:|||||||||:||
pombe   213 HKATIMRMADGLFLECAKELAPEYPDIELREEILDNACLKIVTDPVPYNNTVMVMPNLYGDIVSD 277

  Fly   278 MCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHMELNTYADKI 342
            |||||:||||||||||:|...::||:|||||||||||.||||||||||:||||:||.||.||.:|
pombe   278 MCAGLIGGLGLTPSGNIGNQASIFEAVHGTAPDIAGKGLANPTALLLSSVMMLKHMNLNDYAKRI 342

  Fly   343 ERAAFETIKEG-KYLTGDLGGRAKCSEFTNEICAKL 377
            |.|.|:|:... ...|.||||::...::|:.|.:||
pombe   343 ESAIFDTLANNPDARTKDLGGKSNNVQYTDAIISKL 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Idh3a	NP_001259705.1	Iso_dh	46..377	CDD:444908	202/333 (61%)
idh2	NP_595203.2	Iso_dh	44..378	CDD:444908	202/334 (60%)