DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfrx and PFK26

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_012159.1	Gene:	PFK26 / 854699	SGDID:	S000001369	Length:	827	Species:	Saccharomyces cerevisiae

Alignment Length:	821	Identity:	236/821 - (28%)
Similarity:	361/821 - (43%)	Gaps:	199/821 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 YKPLISSVTTDTDPDPDMAPSLSAEGTADQPQKSQREGEVKGASSEAQRTKANPNQILSASNSSS 78
            :||:..|.|:...||.|:||:.|....|.....|.                    .:||.|:...
Yeast     2 FKPVDFSETSPVPPDIDLAPTQSPHHVAPSQDSSY--------------------DLLSRSSDDK 46

  Fly    79 IDEQ----DEDQVGTLPLPLLSINRRTPTLLPRPVPPSSTRFTSSYNDDLCTCSNCAYSSFSSSS 139
            ||.:    ||            :::..|....||:  |.|..:|::|....|..|....|..:|:
Yeast    47 IDAEKGPHDE------------LSKHLPLFQKRPL--SDTPISSNWNSPGITEENTPSDSPENSA 97

  Fly   140 SSASSTS----SSSTSATAAGTALASAAASAVAKKLARSVTATSIMDMPYNTSPSLRVRTT---- 196
            ::..|..    :..|....|................|..||...:.|:...|....|..||
Yeast    98 TNLKSLHRLHINDETQLKNAKIPTNDTTDYMPPSDGANEVTRIDLKDIKSPTRHHKRRPTTIDVP 162

  Fly   197 SLNQLKKTADLAIENELHVCPSVMSEELRKLLPPTSETVMTKPFPIRGERTIADCTTPHVIAMVG 261
            .|.:.|.:.|..|..|                                     |..:..||.|||
Yeast   163 GLTKSKTSPDGLISKE-------------------------------------DSGSKLVIVMVG 190

  Fly   262 LPARGKTFISKKLARYLNWIGISTRVFNLGEYRRHATTAYKSH-------EFFRADNEEAMAIRN 319
            |||.||:||:.||:|:||:.....:|||:|..||...   |.|       :||...|.::..:|:
Yeast   191 LPATGKSFITNKLSRFLNYSLYYCKVFNVGNTRRKFA---KEHGLKDQDSKFFEPKNADSTRLRD 252

  Fly   320 RCANQALHDSCDWLLSGQGSIAVFDATNSTRDRRQ-LIHDIVVKQHGFRLFFVESICDDPQIIEQ 383
            :.|...|.:..|:||.|.||:.:|||||::|:||: ::..|..:....::.|:||:|.|..::::
Yeast   253 KWAMDTLDELLDYLLEGSGSVGIFDATNTSRERRKNVLARIRKRSPHLKVLFLESVCSDHALVQK 317

  Fly   384 NILEVKVSSPDYLNMNTELVVRDFLQRIEHYEERYQPIDEVTESHLSFMKVYNAGKKVVVYNNEG 448
            || .:|:..|||...:.|..::||..|:.:|.:.|:||::  :.:|.::|:.:.||||:.||.:|
Yeast   318 NI-RLKLFGPDYKGKDPESSLKDFKSRLANYLKAYEPIED--DENLQYIKMIDVGKKVIAYNIQG 379

  Fly   449 HVESRIVYYLMNIHITPRTIYLTRHGESEYNLSGLIGGDSNLSARGHQYANALSTFIAQQQ---- 509
            .:.|:.||||:|.::..|.|::||.||||.|:||.|||:|:|:.||.::|.:|..|||:|:
Yeast   380 FLASQTVYYLLNFNLADRQIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARQREIFY 444

  Fly   510 ------------IDG-----LRVWTSWMKRAIQTVA---DVKAPQERWKALNEIDAGHCEEMTYE 554
                        .||     ..||||...|.|.|..   :...|.::.|.|:|:.||..:.|||.
Yeast   445 QNLMQQKKNNENTDGNIYNDFFVWTSMRARTIGTAQYFNEDDYPIKQMKMLDELSAGDYDGMTYP 509

  Fly   555 QIKEKFPEEFKARDVNKFAYRYP--RGESYEDLVARLEPVIMELER-QGNVLVVSHQAVLRCLFA 616
            :||..|||||:.|..:|..||||  .||||.|::.||.|||.|||| :.|||:::|:.|.|.|..
Yeast   510 EIKNNFPEEFEKRQKDKLRYRYPGIGGESYMDVINRLRPVITELERIEDNVLIITHRVVARALLG 574

  Fly   617 YFLDKSADELPYLYVPLHTVIKLTPVAYG----------CKVEHIKLPIDAVDTHRPK------- 664
            ||::.|...:..|.||||.|..|.|..||          ......|:|...::|.|.|
Yeast   575 YFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLWEYDEASDSFSKVPQTDLNTTRVKEVGLVYN 639

  Fly   665 -------PKIP--------------------------GDVSEPGLDGLSGELVAPDGVGKVLIVG 696
                   |..|                          .::||...:.:|    |..|.....::|
Yeast   640 ERRYSVIPTAPPSARSSFASDFLSRKRSNPTSASSSQSELSEQPKNSVS----AQTGSNNTTLIG 700

  Fly   697 DD------------------VATATNGN---GGRVDVQAHQ 716
            .:                  :||.|:.|   ||...:..|:
Yeast   701 SNFNIKNENGDSRIPLSAPLMATNTSNNILDGGGTSISIHR 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	80/218 (37%)
		AAA_33	256..412	CDD:290396	61/163 (37%)
		His_Phos_1	468..651	CDD:278716	88/219 (40%)
PFK26	NP_012159.1	6PF2K	171..396	CDD:396253	84/267 (31%)
PFK26	NP_012159.1	PhoE	397..608	CDD:223483	89/210 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344139
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S630
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1920
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.680