DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pfrx and pfkfb2b

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_005155899.1	Gene:	pfkfb2b / 564852	ZFINID:	ZDB-GENE-120222-1	Length:	559	Species:	Danio rerio

Alignment Length:	444	Identity:	263/444 - (59%)
Similarity:	331/444 - (74%)	Gaps:	12/444 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 PTSETVMTKPFPIRGERTIADCT-------TPHVIAMVGLPARGKTFISKKLARYLNWIGISTRV 287
            |||.....|..| ||:.  ..|:       :|.||.|:||||||||::||||.|||||||:.|:|
Zfish    12 PTSSAEAKKSEP-RGQE--KKCSWASYMTNSPTVIVMIGLPARGKTYMSKKLTRYLNWIGVPTKV 73

  Fly   288 FNLGEYRRHATTAYKSHEFFRADNEEAMAIRNRCANQALHDSCDWLLSGQGSIAVFDATNSTRDR 352
            ||||.|||.|..||||::|||.||||||.||.:||..||.|...:|....|.||||||||:||:|
Zfish    74 FNLGVYRREAVKAYKSYDFFRHDNEEAMKIRKQCALVALQDVKIYLNEEGGQIAVFDATNTTRER 138

  Fly   353 RQLIHDIVVKQHGFRLFFVESICDDPQIIEQNILEVKVSSPDYLNMNTELVVRDFLQRIEHYEER 417
            |.||.|. .:::.:::|||||:||||::|..||||||||||||...:.|.|:.|||:|||.|:..
Zfish   139 RDLILDF-AQENAYKVFFVESVCDDPEVIAANILEVKVSSPDYPEAHRERVMDDFLKRIECYKVT 202

  Fly   418 YQPID-EVTESHLSFMKVYNAGKKVVVYNNEGHVESRIVYYLMNIHITPRTIYLTRHGESEYNLS 481
            |||:| :..:..|||:||.|.|::.:|...:.:::|:|||||||||:...:|||.||||||:|:.
Zfish   203 YQPLDPDEYDKDLSFIKVINVGRRFLVNRVQDYIQSKIVYYLMNIHVHSHSIYLCRHGESEHNIQ 267

  Fly   482 GLIGGDSNLSARGHQYANALSTFIAQQQIDGLRVWTSWMKRAIQTVADVKAPQERWKALNEIDAG 546
            |.|||||.||:||.|:|:||..|:.:.::..|:||||.::|.|||..::..|.|:||.|||||||
Zfish   268 GRIGGDSELSSRGRQFASALHEFVEEHKLSNLKVWTSQLRRTIQTAEELGVPYEQWKILNEIDAG 332

  Fly   547 HCEEMTYEQIKEKFPEEFKARDVNKFAYRYPRGESYEDLVARLEPVIMELERQGNVLVVSHQAVL 611
            .|||||||.|:..|||||..||.:|:.||||.||||:|||.|||||||||||||||||:.||||:
Zfish   333 VCEEMTYEMIQNTFPEEFALRDQDKYHYRYPGGESYQDLVQRLEPVIMELERQGNVLVICHQAVM 397

  Fly   612 RCLFAYFLDKSADELPYLYVPLHTVIKLTPVAYGCKVEHIKLPIDAVDTHRPKP 665
            |||.|||||||||:|.||..|||||:||||||||||||...|.::||:|||.:|
Zfish   398 RCLLAYFLDKSADDLAYLLCPLHTVMKLTPVAYGCKVEMFHLNVEAVNTHRDRP 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	123/211 (58%)
		AAA_33	256..412	CDD:290396	97/155 (63%)
		His_Phos_1	468..651	CDD:278716	125/182 (69%)
pfkfb2b	XP_005155899.1	6PF2K	28..250	CDD:279872	124/222 (56%)
		AAA_33	42..197	CDD:290396	97/155 (63%)
		His_Phos_1	254..437	CDD:278716	125/182 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581945
Domainoid	1	1.000	269	1.000	Domainoid score	I1793
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1127
OMA	1	1.010	-	-		QHG55027
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm25112
orthoMCL	1	0.900	-	-		OOG6_100250
Panther	1	1.100	-	-	O	PTHR10606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810