DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfrx and pfkfb4a

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_001032454.1	Gene:	pfkfb4a / 556190	ZFINID:	ZDB-GENE-051120-51	Length:	482	Species:	Danio rerio

Alignment Length:	489	Identity:	270/489 - (55%)
Similarity:	346/489 - (70%)	Gaps:	22/489 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 IENELHVCPSVMSEE-----LRKLLPPTSETVMTKPFPIR--GERTIADCTTPHVIAMVGLPARG 266
            |||....|.:.::.|     |:|:..|:|...:    |.|  .::.:.....|.:|..|||||||
Zfish     4 IENNTEQCGNSLTRELTQNPLKKIWVPSSRNGL----PDRHISQKKVCMTNCPTLIVTVGLPARG 64

  Fly   267 KTFISKKLARYLNWIGISTRVFNLGEYRRHATTAYKSHEFFRADNEEAMAIRNRCANQALHDSCD 331
            ||:|||||.||||||.:.|:.||:|:|||.....|||.||||.||||.:.||.:||..||:|...
Zfish    65 KTYISKKLTRYLNWIDVPTKEFNVGQYRRECVKIYKSFEFFRPDNEEGLKIRKQCALAALNDVRQ 129

  Fly   332 WLLSGQGSIAVFDATNSTRDRRQLIHDIVVK---QHGFRLFFVESICDDPQIIEQNILEVKVSSP 393
            :|....|.:|||||||:||:||    |.:::   |:||::|||||:|:||.:|.:||::||:.||
Zfish   130 FLTDEGGQVAVFDATNTTRERR----DTIIRFAEQNGFKVFFVESVCEDPDVIAENIVQVKLGSP 190

  Fly   394 DYLNMNTELVVRDFLQRIEHYEERYQPIDEVTESHLSFMKVYNAGKKVVVYNNEGHVESRIVYYL 458
            ||.:.|||..|.||::||:.||..|||:||..:..|||:|:.:.|::.:|...:.|::|||||||
Zfish   191 DYTHCNTEEAVADFMKRIKCYENSYQPLDEELDRDLSFIKIIDVGRRYLVNRVQDHIQSRIVYYL 255

  Fly   459 MNIHITPRTIYLTRHGESEYNLSGLIGGDSNLSARGHQYANALSTFIAQQQIDGLRVWTSWMKRA 523
            ||||||||:|||.|||||:.|:.|.|||||.|||||.:||..|..||..|.|..|:||||.|||.
Zfish   256 MNIHITPRSIYLCRHGESDLNIKGRIGGDSGLSARGKKYAETLGQFIQSQNIHELKVWTSQMKRT 320

  Fly   524 IQTVADVKAPQERWKALNEIDAGHCEEMTYEQIKEKFPEEFKARDVNKFAYRYPRGESYEDLVAR 588
            |||...|..|.|:||||||||||.|||:.||:|::::|.||..||.:|:.||||:||||||||.|
Zfish   321 IQTAEAVGVPYEQWKALNEIDAGVCEELMYEEIQQRYPLEFALRDQDKYRYRYPKGESYEDLVQR 385

  Fly   589 LEPVIMELERQGNVLVVSHQAVLRCLFAYFLDKSADELPYLYVPLHTVIKLTPVAYGCKVEHIKL 653
            |||||||||||.||||:.||||:|||.||||||:|:|||||..|||||:||.|||||||||.|.|
Zfish   386 LEPVIMELERQENVLVICHQAVMRCLLAYFLDKTAEELPYLKCPLHTVLKLAPVAYGCKVESIDL 450

  Fly   654 PIDAVDTHRPKPKIPGDVSEPGLDGLSGELVAPD 687
            .::||:|||.:| ...|||....:.|   |..||
Zfish   451 KVEAVNTHRDRP-TNVDVSRLAEEAL---LTVPD 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	115/213 (54%)
		AAA_33	256..412	CDD:290396	87/158 (55%)
		His_Phos_1	468..651	CDD:278716	126/182 (69%)
pfkfb4a	NP_001032454.1	6PF2K	48..262	CDD:279872	115/217 (53%)
		AAA_33	54..208	CDD:290396	86/157 (55%)
		His_Phos_1	265..448	CDD:278716	126/182 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581948
Domainoid	1	1.000	269	1.000	Domainoid score	I1793
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1127
OMA	1	1.010	-	-		QHG55027
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm25112
orthoMCL	1	0.900	-	-		OOG6_100250
Panther	1	1.100	-	-	O	PTHR10606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770