DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pfrx and pfkfb3

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_998562.1	Gene:	pfkfb3 / 554477	ZFINID:	ZDB-GENE-040426-2724	Length:	536	Species:	Danio rerio

Alignment Length:	481	Identity:	260/481 - (54%)
Similarity:	347/481 - (72%)	Gaps:	23/481 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 LRKLLPPTSETVMTKPFPIRGERTIADCTTPHVIAMVGLPARGKTFISKKLARYLNWIGISTRVF 288
            ::|:..|:.:...:.|...||...:|:  .|.||.||||||||||::|:||.||||||||.|:||
Zfish    10 IQKIWIPSKDDKPSMPRAPRGGPHLAN--PPTVIVMVGLPARGKTYMSRKLTRYLNWIGIPTKVF 72

  Fly   289 NLGEYRRHATTAYKSHEFFRADNEEAMAIRNRCANQALHDSCDWLLSGQGSIAVFDATNSTRDRR 353
            |:|||||.|...|.|::||::|||:|:.||.:||..||.|..::|....|.:|||||||:|||||
Zfish    73 NVGEYRREAVKHYSSYDFFKSDNEDAVKIRQQCALAALRDVKNYLTEEDGQVAVFDATNTTRDRR 137

  Fly   354 QLIHDIVVKQHGFRLFFVESICDDPQIIEQNILEVKVSSPDYLNMNTELVVRDFLQRIEHYEERY 418
            .:|.:... ::||::||:||:|:||.:|..||||||||.|||.:.|....:.||.:|||.|...|
Zfish   138 DMILEFGA-ENGFKIFFIESVCEDPNVIACNILEVKVSCPDYQDCNKTDAMEDFKKRIECYRMNY 201

  Fly   419 QPID-EVTESHLSFMKVYNAGKKVVVYNNEGHVESRIVYYLMNIHITPRTIYLTRHGESEYNLSG 482
            ||:| :..:..|||:||.:.|::.:|...:.|::|||||||||||:.||:|||.|||||::||.|
Zfish   202 QPLDPDQYDRSLSFIKVIDVGRRFLVNRIQDHIQSRIVYYLMNIHVQPRSIYLCRHGESQHNLQG 266

  Fly   483 LIGGDSNLSARGHQYANALSTFIAQQQIDGLRVWTSWMKRAIQTVADVKAPQERWKALNEIDAGH 547
            .:||||.||.||.::|.||:.|:.:|.:..|:||||.:||:|||...:..|.|:||||||||||.
Zfish   267 RLGGDSGLSTRGRKFAGALAKFVEEQNLKDLKVWTSQLKRSIQTAEALNVPYEQWKALNEIDAGV 331

  Fly   548 CEEMTYEQIKEKFPEEFKARDVNKFAYRYPRGESYEDLVARLEPVIMELERQGNVLVVSHQAVLR 612
            |||||||:::|:|||||..||.:|:.||||.||||:|||.|:||||||:|||.||||:.||||:|
Zfish   332 CEEMTYEEVRERFPEEFSLRDQDKYYYRYPSGESYQDLVQRVEPVIMEMERQENVLVICHQAVIR 396

  Fly   613 CLFAYFLDKSADELPYLYVPLHTVIKLTPVAYGCKVEHIKLPIDAVDTHRPKP----KIPGDV-- 671
            ||.||||||||||:|||..|||||:||||||||||||.|.|.::||:|||.:|    :.|..:
Zfish   397 CLLAYFLDKSADEMPYLKCPLHTVLKLTPVAYGCKVESISLNVEAVNTHRERPEEVKRGPSTLIR 461

  Fly   672 -------------SEPGLDGLSGELV 684
                         .:|.:|||...::
Zfish   462 RNSVTPLTSHEPFKKPRIDGLDEPII 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	115/211 (55%)
		AAA_33	256..412	CDD:290396	88/155 (57%)
		His_Phos_1	468..651	CDD:278716	124/182 (68%)
pfkfb3	NP_998562.1	6PF2K	31..249	CDD:279872	116/220 (53%)
pfkfb3	NP_998562.1	His_Phos_1	252..435	CDD:278716	124/182 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581949
Domainoid	1	1.000	269	1.000	Domainoid score	I1793
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1127
OMA	1	1.010	-	-		QHG55027
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm25112
orthoMCL	1	0.900	-	-		OOG6_100250
Panther	1	1.100	-	-	O	PTHR10606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1920
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800