Protein Alignment Pfrx and Pfkfb4

DIOPT Version :10

• Sequence 1: NP_477451.1
• Gene: Pfrx / 32938
• FlyBaseID: FBgn0027621
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_062206.1
• Gene: Pfkfb4 / 54283
• RGDID: 3310
• Length: 469
• Species: Rattus norvegicus
• Alignment Length: 456
• Identity: 258/456 - (56%)
• Similarity: 330/456 - (72%)
• Gaps: 5/456 - (1%)

  Fly   224 LRKLLPPTSETVMTKPFPIRGERTIADCTTPHVIAMVGLPARGKTFISKKLARYLNWIGISTRVF 288
            |:|:..|.|.   .:|.....:|.:.....|.:|.||||||||||:|||||.|||||||:.||.|
  Rat    12 LKKIWMPYSN---GRPALHASQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREF 73

  Fly   289 NLGEYRRHATTAYKSHEFFRADNEEAMAIRNRCANQALHDSCDWLLSGQGSIAVFDATNSTRDRR 353
            |:|:|||.....|||.|||..||||.:.||.:||..||:|...:|....|.:|||||||:||:||
  Rat    74 NVGQYRRDMVKTYKSFEFFLPDNEEGLKIRKQCALAALNDVRKFLSEEGGHVAVFDATNTTRERR 138

  Fly   354 QLIHDIVVKQHGFRLFFVESICDDPQIIEQNILEVKVSSPDYLNMNTELVVRDFLQRIEHYEERY 418
            .:|.:. .:|:|::.|||||||.||::|..||::||:.||||:|.:::....||::|||.||..|
  Rat   139 AMIFNF-GEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSY 202

  Fly   419 QPIDEVTESHLSFMKVYNAGKKVVVYNNEGHVESRIVYYLMNIHITPRTIYLTRHGESEYNLSGL 483
            :.:||..:..||::|:.:.|:..||.....|::|||||||||||:|||:|||.||||||.||.|.
  Rat   203 ESLDEEQDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGR 267

  Fly   484 IGGDSNLSARGHQYANALSTFIAQQQIDGLRVWTSWMKRAIQTVADVKAPQERWKALNEIDAGHC 548
            ||||..||.||.:::..|:.||:.|.|..|:||||.|||.|||...:..|.|:||.|||||||.|
  Rat   268 IGGDPGLSPRGREFSKHLAQFISDQNIKDLKVWTSQMKRTIQTAEALSVPYEQWKVLNEIDAGVC 332

  Fly   549 EEMTYEQIKEKFPEEFKARDVNKFAYRYPRGESYEDLVARLEPVIMELERQGNVLVVSHQAVLRC 613
            ||||||:|::.:|.||..||.:|:.||||:||||||||.||||||||||||.||||:.||||:||
  Rat   333 EEMTYEEIQDHYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRC 397

  Fly   614 LFAYFLDKSADELPYLYVPLHTVIKLTPVAYGCKVEHIKLPIDAVDTHRPKPKIPGDVSEPGLDG 678
            |.||||||:|:|||||..|||||:||||||||||||.|.|.:.||:|||.:|: ..|:|.|..:.
  Rat   398 LLAYFLDKAAEELPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQ-NVDISRPSEEA 461

  Fly   679 L 679
            |
  Rat   462 L 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:396253	112/210 (53%)
		His_Phos_1	468..651	CDD:459751	125/182 (69%)
Pfkfb4	NP_062206.1	6-phosphofructo-2-kinase. /evidence=ECO:0000305|PubMed:1651918	1..249		118/240 (49%)
		6PF2K	30..249	CDD:396253	113/219 (52%)
		Fructose-2,6-bisphosphatase. /evidence=ECO:0000305|PubMed:1651918	250..469		138/214 (64%)
		His_Phos_1	252..438	CDD:459751	126/185 (68%)