DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pfrx and Pfkfb4

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_038937937.1	Gene:	Pfkfb4 / 54283	RGDID:	3310	Length:	506	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	258/493 - (52%)
Similarity:	330/493 - (66%)	Gaps:	42/493 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 LRKLLPPTSETVMTKPFPIRGERTIADCTTPHVIAMVGLPARGKTFISKKLARYLNWIGISTRVF 288
            |:|:..|.|.   .:|.....:|.:.....|.:|.||||||||||:|||||.|||||||:.||.|
  Rat    12 LKKIWMPYSN---GRPALHASQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREF 73

  Fly   289 NLGEYRRHATTAYKSHEFFRADNEEAMAIRNRCANQALHDSCDWLLSGQGSIAVFDATNSTRDRR 353
            |:|:|||.....|||.|||..||||.:.||.:||..||:|...:|....|.:|||||||:||:||
  Rat    74 NVGQYRRDMVKTYKSFEFFLPDNEEGLKIRKQCALAALNDVRKFLSEEGGHVAVFDATNTTRERR 138

  Fly   354 QLIHDIVVKQHGFRLFFVESICDDPQIIEQNILEVKVSSPDYLNMNTELVVRDFLQRIEHYEERY 418
            .:|.:. .:|:|::.|||||||.||::|..||::||:.||||:|.:::....||::|||.||..|
  Rat   139 AMIFNF-GEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSY 202

  Fly   419 QPIDEVTE-------------------------------------SHLSFMKVYNAGKKVVVYNN 446
            :.:||..:                                     ..||::|:.:.|:..||...
  Rat   203 ESLDEEQDRWIPWAELRALQLVPVAAAVLPRAWPPSQALSTFSLARDLSYIKIMDVGQSYVVNRV 267

  Fly   447 EGHVESRIVYYLMNIHITPRTIYLTRHGESEYNLSGLIGGDSNLSARGHQYANALSTFIAQQQID 511
            ..|::|||||||||||:|||:|||.||||||.||.|.||||..||.||.:::..|:.||:.|.|.
  Rat   268 ADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFSKHLAQFISDQNIK 332

  Fly   512 GLRVWTSWMKRAIQTVADVKAPQERWKALNEIDAGHCEEMTYEQIKEKFPEEFKARDVNKFAYRY 576
            .|:||||.|||.|||...:..|.|:||.|||||||.|||||||:|::.:|.||..||.:|:.|||
  Rat   333 DLKVWTSQMKRTIQTAEALSVPYEQWKVLNEIDAGVCEEMTYEEIQDHYPLEFALRDQDKYRYRY 397

  Fly   577 PRGESYEDLVARLEPVIMELERQGNVLVVSHQAVLRCLFAYFLDKSADELPYLYVPLHTVIKLTP 641
            |:||||||||.||||||||||||.||||:.||||:|||.||||||:|:|||||..|||||:||||
  Rat   398 PKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEELPYLKCPLHTVLKLTP 462

  Fly   642 VAYGCKVEHIKLPIDAVDTHRPKPKIPGDVSEPGLDGL 679
            ||||||||.|.|.:.||:|||.:|: ..|:|.|..:.|
  Rat   463 VAYGCKVESIFLNVAAVNTHRDRPQ-NVDISRPSEEAL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	112/247 (45%)
		AAA_33	256..412	CDD:290396	86/155 (55%)
		His_Phos_1	468..651	CDD:278716	125/182 (69%)
Pfkfb4	XP_038937937.1	6PF2K	30..286	CDD:396253	113/256 (44%)
Pfkfb4	XP_038937937.1	His_Phos_1	289..475	CDD:395236	126/185 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341908
Domainoid	1	1.000	274	1.000	Domainoid score	I1700
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1137
OMA	1	1.010	-	-		QHG55027
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm45541
orthoMCL	1	0.900	-	-		OOG6_100250
Panther	1	1.100	-	-	O	PTHR10606
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770