Protein Alignment Pfrx and PFKFB3

DIOPT Version :9

• Sequence 1: NP_477451.1
• Gene: Pfrx / 32938
• FlyBaseID: FBgn0027621
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001350474.1
• Gene: PFKFB3 / 5209
• HGNCID: 8874
• Length: 568
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 262/514 - (50%)
• Similarity: 342/514 - (66%)
• Gaps: 61/514 - (11%)

  Fly   253 TPHVIAMVGLPARGKTFISKKLARYLNWIGISTRVFNLGEYRRHATTAYKSHEFFRADNEEAMAI 317
            :|.||.||||||||||:|||||.|||||||:.|:|||:|||||.|...|.|:.|||.||||||.:
Human    34 SPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKV 98

  Fly   318 RNRCANQALHDSCDWLLSGQGSIAVFDATNSTRDRRQLI-HDIVVKQHGFRLFFVESICDDPQII 381
            |.:||..||.|...:|....|.||||||||:||:||.:| |  ..|::.|:.||:||:||||.::
Human    99 RKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILH--FAKENDFKAFFIESVCDDPTVV 161

  Fly   382 EQNILEVKVSSPDYLNMNTELVVRDFLQRIEHYEERYQPID-EVTESHLSFMKVYNAGKKVVVYN 445
            ..||:|||:|||||.:.|:...:.||::||..||..|||:| :..:..||.:||.:.|::.:|..
Human   162 ASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNR 226

  Fly   446 NEGHVESRIVYYLMNIHITPRTIYLTRHGESEYNLSGLIGGDSNLSARGHQYANALSTFIAQQQI 510
            .:.|::|||||||||||:.||||||.||||:|:||.|.|||||.||:||.::|:|||.|:.:|.:
Human   227 VQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNL 291

  Fly   511 DGLRVWTSWMKRAIQTVADVKAPQERWKALNEIDAGHCEEMTYEQIKEKFPEEFKARDVNKFAYR 575
            ..||||||.:|..|||...::.|.|:||||||||||.|||:|||:|::.:|||:..|:.:|:.||
Human   292 KDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYR 356

  Fly   576 YPRGESYEDLVARLEPVIMELERQGNVLVVSHQAVLRCLFAYFLDKSADELPYLYVPLHTVIKLT 640
            ||.||||:|||.||||||||||||.||||:.||||||||.||||||||:|:|||..|||||:|||
Human   357 YPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLT 421

  Fly   641 PVAYGCKVEHIKLPIDAVDTHR------------------------PKP---------------- 665
            ||||||:||.|.|.:::|.|||                        |:|
Human   422 PVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVAST 486

  Fly   666 --------------KIPGDVSEPGLDGLSGE--LVAPDGVGKVLIVGDDVATATNGNGG 708
                          ::||...:.|:.|...|  :..|:| ..:|.:..:|..|:....|
Human   487 SAALPSCLPPEVPTQLPGQELKSGIPGRDPEPPVQPPEG-QSILWIPREVTVASRSGPG 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	117/212 (55%)
		AAA_33	256..412	CDD:290396	91/156 (58%)
		His_Phos_1	468..651	CDD:278716	123/182 (68%)
PFKFB3	NP_001350474.1	6-phosphofructo-2-kinase	1..245		117/212 (55%)
		6PF2K	26..246	CDD:279872	117/213 (55%)
		His_Phos_1	249..435	CDD:306748	124/185 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148037
Domainoid	1	1.000	273	1.000	Domainoid score	I1786
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1190
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55027
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm41426
orthoMCL	1	0.900	-	-		OOG6_100250
Panther	1	1.100	-	-	O	PTHR10606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770