DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pfrx and PFKFB2

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_006203.2	Gene:	PFKFB2 / 5208	HGNCID:	8873	Length:	505	Species:	Homo sapiens

Alignment Length:	414	Identity:	262/414 - (63%)
Similarity:	323/414 - (78%)	Gaps:	2/414 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 TPHVIAMVGLPARGKTFISKKLARYLNWIGISTRVFNLGEYRRHATTAYKSHEFFRADNEEAMAI 317
            :|.:|.|:||||||||::||||.|||||||:.|:|||||.|||.|..:|||::|||.||||||.|
Human    37 SPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKI 101

  Fly   318 RNRCANQALHDSCDWLLSGQGSIAVFDATNSTRDRRQLIHDIVVKQHGFRLFFVESICDDPQIIE 382
            |.:||..||.|...:|....|.||||||||:||:||.:|.:. .:|:.|::|||||:||||.:|.
Human   102 RKQCALVALEDVKAYLTEENGQIAVFDATNTTRERRDMILNF-AEQNSFKVFFVESVCDDPDVIA 165

  Fly   383 QNILEVKVSSPDYLNMNTELVVRDFLQRIEHYEERYQPID-EVTESHLSFMKVYNAGKKVVVYNN 446
            .||||||||||||...|.|.|:.|||:|||.|:..|:|:| :..:..|||:||.|.|::.:|...
Human   166 ANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRV 230

  Fly   447 EGHVESRIVYYLMNIHITPRTIYLTRHGESEYNLSGLIGGDSNLSARGHQYANALSTFIAQQQID 511
            :.:::|:|||||||||:.||||||.||||||:||.|.|||||.||.||.|:|.||..|:.:|:|.
Human   231 QDYIQSKIVYYLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEIT 295

  Fly   512 GLRVWTSWMKRAIQTVADVKAPQERWKALNEIDAGHCEEMTYEQIKEKFPEEFKARDVNKFAYRY 576
            .|:||||.:||.|||...:..|.|:||.|||||||.||||||.:|::::||||..||..|:.|||
Human   296 DLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRY 360

  Fly   577 PRGESYEDLVARLEPVIMELERQGNVLVVSHQAVLRCLFAYFLDKSADELPYLYVPLHTVIKLTP 641
            |.||||:|||.|||||||||||||||||:|||||:|||.||||||.|||||||..||||:.||||
Human   361 PGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTP 425

  Fly   642 VAYGCKVEHIKLPIDAVDTHRPKP 665
            ||||||||.|||.::||:|||.||
Human   426 VAYGCKVETIKLNVEAVNTHRDKP 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	121/211 (57%)
		AAA_33	256..412	CDD:290396	96/155 (62%)
		His_Phos_1	468..651	CDD:278716	128/182 (70%)
PFKFB2	NP_006203.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		6-phosphofructo-2-kinase	2..248		121/211 (57%)
		6PF2K	26..249	CDD:396253	121/212 (57%)
		Fructose-2,6-bisphosphatase	249..505		141/201 (70%)
		His_Phos_1	252..435	CDD:395236	128/182 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..505		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148035
Domainoid	1	1.000	273	1.000	Domainoid score	I1786
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1190
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55027
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm41426
orthoMCL	1	0.900	-	-		OOG6_100250
Panther	1	1.100	-	-	O	PTHR10606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770