DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pfrx and PFKFB1

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_016885065.1	Gene:	PFKFB1 / 5207	HGNCID:	8872	Length:	500	Species:	Homo sapiens

Alignment Length:	484	Identity:	271/484 - (55%)
Similarity:	337/484 - (69%)	Gaps:	37/484 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 KLLPPTSETVMTKPFPI--------------RGERTIADCTTPHVIAMVGLPARGKTFISKKLAR 276
            |:.|...|...|:...|              ||........:|.::.||||||||||:||.||.|
Human     8 KMSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTR 72

  Fly   277 YLNWIGISTR---------------------VFNLGEYRRHATTAYKSHEFFRADNEEAMAIRNR 320
            ||||||..|:                     |||||:|||.| .:||::|||..||.||:.||.:
Human    73 YLNWIGTPTKARTFFWPLGSSQPLHWHSLLSVFNLGQYRREA-VSYKNYEFFLPDNMEALQIRKQ 136

  Fly   321 CANQALHDSCDWLLSGQGSIAVFDATNSTRDRRQLIHDIVVKQHGFRLFFVESICDDPQIIEQNI 385
            ||..||.|..::|...:|.:|||||||:||:||.||... .|:||:::||:||||:||.||.:||
Human   137 CALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQF-AKEHGYKVFFIESICNDPGIIAENI 200

  Fly   386 LEVKVSSPDYLNMNTELVVRDFLQRIEHYEERYQPIDEVTESHLSFMKVYNAGKKVVVYNNEGHV 450
            .:||:.||||::.:.|.|:.|||:|||.||..|||:||..:||||::|:::.|.:.:|...:.|:
Human   201 RQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHI 265

  Fly   451 ESRIVYYLMNIHITPRTIYLTRHGESEYNLSGLIGGDSNLSARGHQYANALSTFIAQQQIDGLRV 515
            :||.||||||||:|||:|||.||||||.|:.|.|||||.||.||.|||.||:.||..|.|..|:|
Human   266 QSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKV 330

  Fly   516 WTSWMKRAIQTVADVKAPQERWKALNEIDAGHCEEMTYEQIKEKFPEEFKARDVNKFAYRYPRGE 580
            |||.|||.|||...:..|.|:||||||||||.|||||||:|:|.:||||..||.:|:.||||:||
Human   331 WTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGE 395

  Fly   581 SYEDLVARLEPVIMELERQGNVLVVSHQAVLRCLFAYFLDKSADELPYLYVPLHTVIKLTPVAYG 645
            ||||||.||||||||||||.||||:.||||:|||.|||||||:||||||..|||||:||||||||
Human   396 SYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYG 460

  Fly   646 CKVEHIKLPIDAVDTHRPKPKIPGDVSEP 674
            ||||.|.|.::||:|||.||:......||
Human   461 CKVESIYLNVEAVNTHREKPENVDITREP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	117/231 (51%)
		AAA_33	256..412	CDD:290396	89/176 (51%)
		His_Phos_1	468..651	CDD:278716	133/182 (73%)
PFKFB1	XP_016885065.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148034
Domainoid	1	1.000	273	1.000	Domainoid score	I1786
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1190
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55027
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm41426
orthoMCL	1	0.900	-	-		OOG6_100250
Panther	1	1.100	-	-	LDO	PTHR10606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1920
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800