DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfrx and pfkfb4b

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_005166082.1	Gene:	pfkfb4b / 386663	ZFINID:	ZDB-GENE-031031-4	Length:	485	Species:	Danio rerio

Alignment Length:	469	Identity:	261/469 - (55%)
Similarity:	334/469 - (71%)	Gaps:	32/469 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 LLPPTSETVMTKPFPIRGERT-----------------------------IADCTTPHVIAMVGL 262
            :.|.|.:...|..:..|.|||                             :.:|  |.:|..|||
Zfish     1 MFPQTDDDKHTLCYTTRAERTDPALLFNITWTMRNSSRFQDGHRRDGTVCMTNC--PTLIVTVGL 63

  Fly   263 PARGKTFISKKLARYLNWIGISTRVFNLGEYRRHATTAYKSHEFFRADNEEAMAIRNRCANQALH 327
            ||||||:|||||.|||||||:.|..||:|:|||.....|||.||||.||||.:.||.:||:.||:
Zfish    64 PARGKTYISKKLTRYLNWIGVPTHEFNVGQYRRECVKIYKSFEFFRPDNEEGLKIRKQCASAALN 128

  Fly   328 DSCDWLLSGQGSIAVFDATNSTRDRRQLIHDIVVKQHGFRLFFVESICDDPQIIEQNILEVKVSS 392
            |..::|....|.:|||||||:||:||.:|... ..|:|:::|||||:|:||::|.:||::||:.|
Zfish   129 DVREYLSVEGGQVAVFDATNTTRERRNIIMKF-ADQNGYKVFFVESVCEDPKVIAENIVQVKLGS 192

  Fly   393 PDYLNMNTELVVRDFLQRIEHYEERYQPIDEVTESHLSFMKVYNAGKKVVVYNNEGHVESRIVYY 457
            |||.:.|||..::||::||:.||..|||:||..:..||::|:.:.|::.:|.....|::||||||
Zfish   193 PDYTDRNTEEAIQDFMKRIKCYESSYQPLDENLDRELSYIKIMDVGQRYLVNRVLDHIQSRIVYY 257

  Fly   458 LMNIHITPRTIYLTRHGESEYNLSGLIGGDSNLSARGHQYANALSTFIAQQQIDGLRVWTSWMKR 522
            |||||||||:|||.|||||:.|:.|.|||||.||.||.::|::|..||..|.|..|:||||.|||
Zfish   258 LMNIHITPRSIYLCRHGESDLNVRGRIGGDSGLSHRGKEFAHSLGRFIQDQNIKDLKVWTSQMKR 322

  Fly   523 AIQTVADVKAPQERWKALNEIDAGHCEEMTYEQIKEKFPEEFKARDVNKFAYRYPRGESYEDLVA 587
            .|||...:..|.|:||||||||||.||||.||:|:|.:|:||..||.:|:.||||:||||||||.
Zfish   323 TIQTAESLGVPYEQWKALNEIDAGVCEEMMYEEIQEHYPQEFALRDQDKYRYRYPKGESYEDLVQ 387

  Fly   588 RLEPVIMELERQGNVLVVSHQAVLRCLFAYFLDKSADELPYLYVPLHTVIKLTPVAYGCKVEHIK 652
            ||||||||||||.||||:.||||:|||.||||||||||||||..|||||:||||||||||||.|.
Zfish   388 RLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSADELPYLKCPLHTVLKLTPVAYGCKVESIY 452

  Fly   653 LPIDAVDTHRPKPK 666
            |.::||:|||.||:
Zfish   453 LNVEAVNTHRDKPE 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	113/210 (54%)
		AAA_33	256..412	CDD:290396	86/155 (55%)
		His_Phos_1	468..651	CDD:278716	128/182 (70%)
pfkfb4b	XP_005166082.1	6PF2K	51..265	CDD:279872	114/216 (53%)
		AAA_33	57..211	CDD:290396	85/154 (55%)
		His_Phos_1	268..451	CDD:278716	128/182 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581947
Domainoid	1	1.000	269	1.000	Domainoid score	I1793
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1127
OMA	1	1.010	-	-		QHG55027
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm25112
orthoMCL	1	0.900	-	-		OOG6_100250
Panther	1	1.100	-	-	O	PTHR10606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770