DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pfrx and Ubash3a

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_808491.2	Gene:	Ubash3a / 328795	MGIID:	1926074	Length:	624	Species:	Mus musculus

Alignment Length:	397	Identity:	92/397 - (23%)
Similarity:	140/397 - (35%)	Gaps:	118/397 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 HATTAYKSHEFFRADNEE-AMAIRNRCANQALHDSCDWLLSGQGSIAVFDATNSTRDRRQLIHDI 359
            |.|.|:|.:...:...|: |.||      |..| ||.|      :.|::     :||.| .:|..
Mouse   196 HLTLAHKFYPHHQRTLEQLAKAI------QPSH-SCQW------TAALY-----SRDMR-FVHYQ 241

  Fly   360 VVKQHGFRLFFVESICDDPQIIEQNILEVKVSSPDY----------------LNMNTELVVRDFL 408
            .:|    .||         |...||..|:.:|:.||                :.::.....|.||
Mouse   242 TLK----ALF---------QYKPQNADELMLSAGDYIFVDPTQQEEASEGWAIGISHRTGCRGFL 293

  Fly   409 QRIEHYEERYQPIDEVTESH---------LSFMKVYNAGKKVVVYNNEGHVE--SRIVYYLMNIH 462
            .  |:|.||....|...:..         |:..|.:.|..:   .|.|.|..  |:.|..:..:.
Mouse   294 P--ENYTERANEADTWVKHRTYTFNLAMDLNSRKDFEASCR---GNGEPHTPSMSKSVSSIQALQ 353

  Fly   463 --ITPRTIYLTRHGESEYNLSGLIGGDSNLSARGHQY-------------ANALSTF-------- 504
              |:.|.|.:.||||....:.|........:|.|..|             :|.:..|
Mouse   354 ATISRRGILVVRHGERVDQVFGKSWLQQCTTADGKYYRPDLNFPRSLPRRSNGIKDFENDPPLSS 418

  Fly   505 --IAQQQI-------DGLR---VWTSWMKRAIQTVADVKAPQERWKALN-EIDAGHCEEMTYEQI 556
              |.|.::       .|:|   |:.|...|.:||...:....:..|.|. .::.|..|.|.:|..
Mouse   419 CGIFQARLAGEALLDSGVRVTAVFASPALRCVQTAKHILEELKLEKKLKIRVEPGIFEWMKWEAS 483

  Fly   557 KEKFP----EEFKARDVN-KFAYR--YPR-----GESYEDLVARLEPVIMEL-----ERQGNVLV 604
            |....    ||.|..:.| ...||  .||     .|||:..|.|....:.::     :..|..|:
Mouse   484 KATLTFLTLEELKEANFNVDLDYRPALPRCSLMPAESYDQYVERCAVSMGQIINTCPQDMGITLI 548

  Fly   605 VSHQAVL 611
            |||.:.|
Mouse   549 VSHSSAL 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	45/198 (23%)
		AAA_33	256..412	CDD:290396	31/132 (23%)
		His_Phos_1	468..651	CDD:278716	46/195 (24%)
Ubash3a	NP_808491.2	UBA_UBS3A_like	25..61	CDD:270485
		SH3_UBASH3A	241..300	CDD:212870	15/73 (21%)
		Phosphatase-like	358..624		47/198 (24%)
		HP	361..>456	CDD:132716	20/94 (21%)
		His_Phos_1	413..575	CDD:278716	35/143 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900