Protein Alignment Pfrx and Pfkfb1

DIOPT Version :10

• Sequence 1: NP_477451.1
• Gene: Pfrx / 32938
• FlyBaseID: FBgn0027621
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_036753.4
• Gene: Pfkfb1 / 24638
• RGDID: 3307
• Length: 471
• Species: Rattus norvegicus
• Alignment Length: 457
• Identity: 273/457 - (59%)
• Similarity: 342/457 - (74%)
• Gaps: 15/457 - (3%)

  Fly   220 MSEE--------LRKLLPP--TSETVMTKPFPIRGERTIADCTTPHVIAMVGLPARGKTFISKKL 274
            ||.|        |:|:..|  :|.:|:.:.   ||........:|.::.||||||||||:||.||
  Rat     1 MSREMGELTQTRLQKIWIPHSSSSSVLQRR---RGSSIPQFTNSPTMVIMVGLPARGKTYISTKL 62

  Fly   275 ARYLNWIGISTRVFNLGEYRRHATTAYKSHEFFRADNEEAMAIRNRCANQALHDSCDWLLSGQGS 339
            .|||||||..|:|||||:|||.| .:|:::||||.||.||..||.:||..||.|...:|...:|.
  Rat    63 TRYLNWIGTPTKVFNLGQYRREA-VSYRNYEFFRPDNTEAQLIRKQCALAALKDVHKYLSREEGH 126

  Fly   340 IAVFDATNSTRDRRQLIHDIVVKQHGFRLFFVESICDDPQIIEQNILEVKVSSPDYLNMNTELVV 404
            :|||||||:||:||.||... .|:||:::||:||||:||:||.:||.:||:.||||::.:.|.|:
  Rat   127 VAVFDATNTTRERRSLILQF-AKEHGYKVFFIESICNDPEIIAENIKQVKLGSPDYIDCDQEKVL 190

  Fly   405 RDFLQRIEHYEERYQPIDEVTESHLSFMKVYNAGKKVVVYNNEGHVESRIVYYLMNIHITPRTIY 469
            .|||:|||.||..|||:||..:||||::|:::.|.:.:|...:.||:||..|||||||:|||:||
  Rat   191 EDFLKRIECYEINYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHVQSRTAYYLMNIHVTPRSIY 255

  Fly   470 LTRHGESEYNLSGLIGGDSNLSARGHQYANALSTFIAQQQIDGLRVWTSWMKRAIQTVADVKAPQ 534
            |.||||||.||.|.|||||.|||||.|||.||:.||..|.|..|:||||.|||.|||...:..|.
  Rat   256 LCRHGESELNLRGRIGGDSGLSARGKQYAYALANFIRSQGISSLKVWTSHMKRTIQTAEALGVPY 320

  Fly   535 ERWKALNEIDAGHCEEMTYEQIKEKFPEEFKARDVNKFAYRYPRGESYEDLVARLEPVIMELERQ 599
            |:||||||||||.|||||||:|:|.:||||..||.:|:.||||:||||||||.||||||||||||
  Rat   321 EQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQ 385

  Fly   600 GNVLVVSHQAVLRCLFAYFLDKSADELPYLYVPLHTVIKLTPVAYGCKVEHIKLPIDAVDTHRPK 664
            .||||:.||||:|||.|||||||:||||||..|||||:|||||||||:||.|.|.::||:|||.|
  Rat   386 ENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCRVESIYLNVEAVNTHRDK 450

  Fly   665 PK 666
            |:
  Rat   451 PE 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:396253	117/210 (56%)
		His_Phos_1	468..651	CDD:459751	134/182 (74%)
Pfkfb1	NP_036753.4	6-phosphofructo-2-kinase	2..250		126/252 (50%)
		6PF2K	30..251	CDD:396253	119/225 (53%)
		Fructose-2,6-bisphosphatase	251..471		145/202 (72%)
		His_Phos_1	254..440	CDD:459751	135/185 (73%)