Protein Alignment Pfrx and Pfkfb1

DIOPT Version :10

• Sequence 1: NP_477451.1
• Gene: Pfrx / 32938
• FlyBaseID: FBgn0027621
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_001361102.1
• Gene: Pfkfb1 / 18639
• MGIID: 107816
• Length: 471
• Species: Mus musculus
• Alignment Length: 464
• Identity: 273/464 - (58%)
• Similarity: 342/464 - (73%)
• Gaps: 13/464 - (2%)

  Fly   220 MSEELRKL---------LPPTSETVMTKPFPIRGERTIADCTTPHVIAMVGLPARGKTFISKKLA 275
            ||.|:.:|         :|.:|.:.:.:  ..||........:|.::.||||||||||:||.||.
Mouse     1 MSREMGELTQTRLQKIWIPHSSSSSLLQ--RRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLT 63

  Fly   276 RYLNWIGISTRVFNLGEYRRHATTAYKSHEFFRADNEEAMAIRNRCANQALHDSCDWLLSGQGSI 340
            |||||||..|:|||||:|||.| .:|:::||||.||.||..||.:||..||.|...:|...:|.:
Mouse    64 RYLNWIGTPTKVFNLGQYRREA-VSYRNYEFFRPDNMEAQLIRKQCALAALKDVHKYLSREEGHV 127

  Fly   341 AVFDATNSTRDRRQLIHDIVVKQHGFRLFFVESICDDPQIIEQNILEVKVSSPDYLNMNTELVVR 405
            |||||||:||:||.||... .|:||:::||:||||:||.||.:||.:||:.||||::.:.|.|:.
Mouse   128 AVFDATNTTRERRSLILQF-AKEHGYKVFFIESICNDPDIIAENIKQVKLGSPDYIDCDQEKVLE 191

  Fly   406 DFLQRIEHYEERYQPIDEVTESHLSFMKVYNAGKKVVVYNNEGHVESRIVYYLMNIHITPRTIYL 470
            |||:|||.||..|||:||..:||||::|:::.|.:.:|...:.||:||..|||||||:|||:|||
Mouse   192 DFLKRIECYEINYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHVQSRTAYYLMNIHVTPRSIYL 256

  Fly   471 TRHGESEYNLSGLIGGDSNLSARGHQYANALSTFIAQQQIDGLRVWTSWMKRAIQTVADVKAPQE 535
            .||||||.||.|.|||||.|||||.|||.||:.||..|.|..|:||||.|||.|||...:..|.|
Mouse   257 CRHGESELNLRGRIGGDSGLSARGKQYAYALANFIRSQSISSLKVWTSHMKRTIQTAEALGVPYE 321

  Fly   536 RWKALNEIDAGHCEEMTYEQIKEKFPEEFKARDVNKFAYRYPRGESYEDLVARLEPVIMELERQG 600
            :||||||||||.|||||||:|:|.:||||..||.:|:.||||:||||||||.||||||||||||.
Mouse   322 QWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQE 386

  Fly   601 NVLVVSHQAVLRCLFAYFLDKSADELPYLYVPLHTVIKLTPVAYGCKVEHIKLPIDAVDTHRPKP 665
            ||||:.||||:|||.|||||||:||||||..|||||:|||||||||:||.|.|.::||:|||.||
Mouse   387 NVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCRVESIYLNVEAVNTHRDKP 451

  Fly   666 KIPGDVSEP 674
            :......||
Mouse   452 ENVDITREP 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:396253	117/210 (56%)
		His_Phos_1	468..651	CDD:459751	134/182 (74%)
Pfkfb1	NP_001361102.1	6-phosphofructo-2-kinase. /evidence=ECO:0000250	2..250		124/251 (49%)
		6PF2K	30..251	CDD:396253	119/222 (54%)
		Fructose-2,6-bisphosphatase. /evidence=ECO:0000250	251..471		147/210 (70%)
		His_Phos_1	254..440	CDD:459751	135/185 (73%)