DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfrx and pfkb-1.2

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_500893.2	Gene:	pfkb-1.2 / 177363	WormBaseID:	WBGene00019295	Length:	457	Species:	Caenorhabditis elegans

Alignment Length:	450	Identity:	231/450 - (51%)
Similarity:	309/450 - (68%)	Gaps:	11/450 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 LPPTSETVMTKPFPIRGERTIAD-CTTPHVIAMVGLPARGKTFISKKLARYLNWIGISTRVFNLG 291
            :||..||...| .....|...:| ...|:||.||||||||||:|||||.|||.|.|.:|:|||:|
Worm     3 IPPGLETTKRK-VAHSDEHGFSDQVRVPNVIVMVGLPARGKTYISKKLCRYLKWTGFTTKVFNVG 66

  Fly   292 EYRR-HATTAYKSH----EFFRADNEEAMAIRNRCANQALHDSCDWLLSGQGSIAVFDATNSTRD 351
            |||| .|..|...|    .||..:|.:|:.:|...|.:|:.|..|:|.||.|.:|:|||||:|:|
Worm    67 EYRRSDANAADAIHGANASFFSPNNADALKVRAESARRAMEDMADYLNSGTGGVAIFDATNTTKD 131

  Fly   352 RRQLIHDIVVKQHGFRLFFVESICDDPQIIEQNILEVKVSSPDYLN-MNTELVVRDFLQRIEHYE 415
            ||::|.|...||. .|.||:||:||||.||:.|:.:|||:||||.. |..|....||:.|||:|:
Worm   132 RRRIIIDFCKKQR-LRCFFIESVCDDPAIIDCNVTDVKVNSPDYKGLMTAEQAKEDFMNRIENYK 195

  Fly   416 ERYQPIDEVTESHLSFMKVYNAGKKVVVYNNEGHVESRIVYYLMNIHITPRTIYLTRHGESEYNL 480
            ::|:|:||..:..|||:||.|||:...|:...|||:||:||:|||||:.||:|||||||:||||.
Worm   196 KQYEPLDESEDESLSFIKVINAGRSFKVHQVRGHVQSRVVYFLMNIHLLPRSIYLTRHGQSEYNA 260

  Fly   481 SGLIGGDSNLSARGHQYANALSTFIAQQQIDGLRVWTSWMKRAIQTVADVKAP--QERWKALNEI 543
            .|.:||||.|:..|.:||:||:.|..::::.|||||.|...||.||...:|..  .|.||||:|:
Worm   261 MGRLGGDSPLTEDGQKYASALADFFEEEEVPGLRVWCSQKVRAAQTAQHLKPDFHTEYWKALDEL 325

  Fly   544 DAGHCEEMTYEQIKEKFPEEFKARDVNKFAYRYPRGESYEDLVARLEPVIMELERQGNVLVVSHQ 608
            |||.||.:|||.|.:::|::...|..:|:.||||.||||||:|:||||||||||||.||||||||
Worm   326 DAGICEGLTYEDILQRYPKQADDRATDKYHYRYPSGESYEDVVSRLEPVIMELERQANVLVVSHQ 390

  Fly   609 AVLRCLFAYFLDKSADELPYLYVPLHTVIKLTPVAYGCKVEHIKLPIDAVDTHRPKPKIP 668
            |||||:.|||.|:...||||:.:|||:::||||.||.|......|.:::.:......::|
Worm   391 AVLRCVLAYFYDRPLSELPYIDIPLHSLVKLTPRAYHCDSTIYALDLESGEWTETSDQLP 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	114/216 (53%)
		AAA_33	256..412	CDD:290396	85/161 (53%)
		His_Phos_1	468..651	CDD:278716	106/184 (58%)
pfkb-1.2	NP_500893.2	6PF2K	23..245	CDD:279872	115/222 (52%)
pfkb-1.2	NP_500893.2	His_Phos_1	248..428	CDD:278716	105/179 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159972
Domainoid	1	1.000	231	1.000	Domainoid score	I1378
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	474	1.000	Inparanoid score	I823
Isobase	1	0.950	-	0	Normalized mean entropy	S630
OMA	1	1.010	-	-		QHG55027
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm14659
orthoMCL	1	0.900	-	-		OOG6_100250
Panther	1	1.100	-	-	LDO	PTHR10606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.720