DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pfrx and Pfkfb3

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	NP_476476.1	Gene:	Pfkfb3 / 117276	RGDID:	619776	Length:	555	Species:	Rattus norvegicus

Alignment Length:	448	Identity:	259/448 - (57%)
Similarity:	330/448 - (73%)	Gaps:	17/448 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 TPHVIAMVGLPARGKTFISKKLARYLNWIGISTRVFNLGEYRRHATTAYKSHEFFRADNEEAMAI 317
            :|.||.||||||||||:|||||.|||||||:.|:|||:|||||.|...|.|:.|||.||||||.:
  Rat    34 SPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMRV 98

  Fly   318 RNRCANQALHDSCDWLLSGQGSIAVFDATNSTRDRRQLI-HDIVVKQHGFRLFFVESICDDPQII 381
            |.:||..||.|...:|....|.||||||||:||:||.:| |  ..|::.|:.||:||:||||.::
  Rat    99 RKQCALAALRDVKSYLTKEGGQIAVFDATNTTRERRHMILH--FAKENDFKAFFIESVCDDPTVV 161

  Fly   382 EQNILEVKVSSPDYLNMNTELVVRDFLQRIEHYEERYQPID-EVTESHLSFMKVYNAGKKVVVYN 445
            ..||:|||:|||||.:.|:...:.||::||..||..|||:| :..:..|||:||.:.|::.:|..
  Rat   162 ASNIMEVKISSPDYKDCNSAEAMDDFMKRINCYEASYQPLDPDKCDRDLSFIKVIDVGRRFLVNR 226

  Fly   446 NEGHVESRIVYYLMNIHITPRTIYLTRHGESEYNLSGLIGGDSNLSARGHQYANALSTFIAQQQI 510
            .:.|::|||||||||||:.||||||.||||:|||:.|.|||||.||:||.::|||||.|:.:|.:
  Rat   227 VQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEYNVQGKIGGDSGLSSRGKKFANALSKFVEEQNL 291

  Fly   511 DGLRVWTSWMKRAIQTVADVKAPQERWKALNEIDAGHCEEMTYEQIKEKFPEEFKARDVNKFAYR 575
            ..||||||.:|..|||...::.|.|:||||||||||.|||:|||:|::.:|||:..|:.:|:.||
  Rat   292 KDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYR 356

  Fly   576 YPRGESYEDLVARLEPVIMELERQGNVLVVSHQAVLRCLFAYFLDKSADELPYLYVPLHTVIKLT 640
            ||.||||:|||.||||||||||||.||||:.||||||||.||||||||:|:|||..|||||:|||
  Rat   357 YPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLT 421

  Fly   641 PVAYGCKVEHIKLPIDAVDTHRPKPKI-----------PGDVSEPGLDGLSGELVAPD 687
            ||||||:||.|.|.:::|.|||.:.:.           |...:|  ||.||.|....|
  Rat   422 PVAYGCRVESIYLNVESVSTHRERSEAVKIQHFASVVRPSSYTE--LDFLSVESAKQD 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	118/212 (56%)
		AAA_33	256..412	CDD:290396	91/156 (58%)
		His_Phos_1	468..651	CDD:278716	124/182 (68%)
Pfkfb3	NP_476476.1	6-phosphofructo-2-kinase	1..245		118/212 (56%)
		6PF2K	26..246	CDD:396253	118/213 (55%)
		Fructose-2,6-bisphosphatase	246..555		141/234 (60%)
		His_Phos_1	249..435	CDD:395236	125/185 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..504		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341909
Domainoid	1	1.000	274	1.000	Domainoid score	I1700
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1137
OMA	1	1.010	-	-		QHG55027
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm45541
orthoMCL	1	0.900	-	-		OOG6_100250
Panther	1	1.100	-	-	O	PTHR10606
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770