DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfrx and pfkfb1

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_004919688.1	Gene:	pfkfb1 / 100488795	XenbaseID:	XB-GENE-957710	Length:	525	Species:	Xenopus tropicalis

Alignment Length:	498	Identity:	281/498 - (56%)
Similarity:	342/498 - (68%)	Gaps:	46/498 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 MSEELRKL---------LPPTSETVMTKPFPIRGERTIADCTTPHVIAMVGLPARGKTFISKKLA 275
            |:|.||:|         :|...|.:..:    ||........:|.:|.||||||||||:|||||.
Frog    28 MAEILRELKQTRLQKIWIPHQCERLQQR----RGSSIPQFTNSPTMIIMVGLPARGKTYISKKLT 88

  Fly   276 RYLNWIGISTRVFNLGEYRRHATTAYKSHEFFRADNEEAMAIRNRCANQALHDSCDWLLSGQGSI 340
            ||||||||.|:|||:|:|||.....||::|||..||:|||.||.:||..||.|...:|...:|.:
Frog    89 RYLNWIGIPTKVFNVGQYRREVVQTYKNYEFFHPDNQEAMKIRKQCALSALRDVDKYLTQEEGQV 153

  Fly   341 AVFDATNSTRDRRQLIHDIVVKQHGFRLFFVESICDDPQIIEQNILEVKVSSPDYLNMNTELVVR 405
            |||||||:||:||.||... .|:..|:.||:|||||||.||.:||:|||:|||||.:.:.|.||.
Frog   154 AVFDATNTTRERRSLILQF-AKERVFKAFFIESICDDPDIIAENIMEVKLSSPDYKDCDREKVVE 217

  Fly   406 DFLQRIEHYEERYQPIDEVTESHLSFMKVYNAGKKVVVYNNEGHVESRIVYYLMNIHITPRTIYL 470
            |||:|||.|...|||:.:..:|.||::|::|.|.:.:|...:.|::||.||||||||:|||:|||
Frog   218 DFLKRIECYNMYYQPLHDDLDSSLSYIKIFNVGSRYLVNRVQDHIQSRAVYYLMNIHVTPRSIYL 282

  Fly   471 TRHGESEYNLSGLIGGDSNLSARGHQYANALSTFIAQQQIDGLRVWTSWMKRAIQTVADVKAPQE 535
            .||||||.||.|.|||||.||.||.|:|:||..|:..|||..|:||||.|||.|||...:..|.|
Frog   283 CRHGESELNLLGRIGGDSGLSTRGKQFAHALGNFVKSQQITDLKVWTSHMKRTIQTAEALGVPYE 347

  Fly   536 RWKALNEIDAGHCEEMTYEQIKEKFPEEFKARDVNKFAYRYPRGESYEDLVARLEPVIMELERQG 600
            :||||||||||.|||||||:|:|:|||||..||.:|:.||||:||||||||.||||||||||||.
Frog   348 QWKALNEIDAGVCEEMTYEEIQERFPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQE 412

  Fly   601 NVLVVSHQAVLRCLFAYFLDKS----------------------------ADELPYLYVPLHTVI 637
            |||||.||||:|||.|||||||                            |::||||..|||||:
Frog   413 NVLVVCHQAVMRCLLAYFLDKSAGKQTRHCIICCRWTWVSLIFMIYSPPPAEQLPYLKCPLHTVL 477

  Fly   638 KLTPVAYGCKVEHIKLPIDAVDTHRPKPKIPGDVS---EPGLD 677
            ||||||||||||.|.|.|:||:|||.|| ...|||   |..||
Frog   478 KLTPVAYGCKVESIYLNIEAVNTHREKP-FNVDVSRDPEEALD 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	119/210 (57%)
		AAA_33	256..412	CDD:290396	94/155 (61%)
		His_Phos_1	468..651	CDD:278716	134/210 (64%)
pfkfb1	XP_004919688.1	6PF2K	58..277	CDD:334602	119/219 (54%)
pfkfb1	XP_004919688.1	His_Phos_1	280..434	CDD:366010	110/153 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1721
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1139
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm48632
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060