DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pfrx and si:dkey-96f10.1

DIOPT Version :9

Sequence 1:	NP_477451.1	Gene:	Pfrx / 32938	FlyBaseID:	FBgn0027621	Length:	716	Species:	Drosophila melanogaster
Sequence 2:	XP_002666487.2	Gene:	si:dkey-96f10.1 / 100330415	ZFINID:	ZDB-GENE-090312-154	Length:	465	Species:	Danio rerio

Alignment Length:	445	Identity:	265/445 - (59%)
Similarity:	337/445 - (75%)	Gaps:	5/445 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 RGERTIADCTTPHVIAMVGLPARGKTFISKKLARYLNWIGISTRVFNLGEYRRHATTAYKSHEFF 307
            ||........:|.:|.|:||||||||:|||||.|||||||:.|:|||:|:|||.|...|||:|||
Zfish    24 RGSSVPQFTNSPTMIVMIGLPARGKTYISKKLTRYLNWIGVPTKVFNVGQYRRDAVRTYKSYEFF 88

  Fly   308 RADNEEAMAIRNRCANQALHDSCDWLLSGQGSIAVFDATNSTRDRRQLIHDIVVKQHGFRLFFVE 372
            |.||||||.||..||..||.|.|.:.....|.:|||||||:|::||::|... .|::|:::||||
Zfish    89 RPDNEEAMKIRKTCALAALKDVCCYFTQFHGQVAVFDATNTTKERREMILSF-AKENGYKVFFVE 152

  Fly   373 SICDDPQIIEQNILEVKVSSPDYLNMNTELVVRDFLQRIEHYEERYQPIDEVTESHLSFMKVYNA 437
            |:||||:||.:||.:||::||||.:.:.|..|.|||:||:.|:..|.|:|:..:.:||::|:::.
Zfish   153 SLCDDPEIIAENIKQVKLNSPDYFDCDKEEAVEDFLKRIDCYKLTYVPLDDDKDRNLSYIKIFDV 217

  Fly   438 GKKVVVYNNEGHVESRIVYYLMNIHITPRTIYLTRHGESEYNLSGLIGGDSNLSARGHQYANALS 502
            |.:.:|.:.:.|::|||||||||||:|||||||.||||||.||.|.|||||.||:||.::|.||.
Zfish   218 GSRYLVNHVQDHIQSRIVYYLMNIHVTPRTIYLCRHGESELNLLGRIGGDSGLSSRGMKFAAALG 282

  Fly   503 TFIAQQQIDGLRVWTSWMKRAIQTVADVKAPQERWKALNEIDAGHCEEMTYEQIKEKFPEEFKAR 567
            |:|..|.|..|::|||.|:|.|||...|..|.|:||||||||||.|||||||:|:|.|||||..|
Zfish   283 TYIRGQHILDLKIWTSHMRRTIQTAEAVGVPYEQWKALNEIDAGVCEEMTYEEIQEHFPEEFALR 347

  Fly   568 DVNKFAYRYPRGESYEDLVARLEPVIMELERQGNVLVVSHQAVLRCLFAYFLDKSADELPYLYVP 632
            |.:|:.||||:||||||||.||||||||||||.||||:.||||:|||.||||||:|||||||..|
Zfish   348 DQDKYRYRYPKGESYEDLVHRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKTADELPYLKCP 412

  Fly   633 LHTVIKLTPVAYGCKVEHIKLPIDAVDTHRPKPKIPGDVSEPGLDGLSGELVAPD 687
            ||||:||||||||||||.:.|.::||:|||.:|: ..||.....|.|   |..|:
Zfish   413 LHTVMKLTPVAYGCKVESVFLNVEAVNTHRERPE-NVDVDRDPEDAL---LTVPE 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfrx	NP_477451.1	6PF2K	254..465	CDD:279872	114/210 (54%)
		AAA_33	256..412	CDD:290396	91/155 (59%)
		His_Phos_1	468..651	CDD:278716	132/182 (73%)
si:dkey-96f10.1	XP_002666487.2	6PF2K	23..245	CDD:279872	116/221 (52%)
		AAA_33	37..192	CDD:290396	91/155 (59%)
		His_Phos_1	248..431	CDD:278716	132/182 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581951
Domainoid	1	1.000	269	1.000	Domainoid score	I1793
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1127
OMA	1	1.010	-	-		QHG55027
OrthoDB	1	1.010	-	-		D232517at33208
OrthoFinder	1	1.000	-	-		FOG0000312
OrthoInspector	1	1.000	-	-		otm25112
orthoMCL	1	0.900	-	-		OOG6_100250
Panther	1	1.100	-	-	O	PTHR10606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910